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Impact of Anti-miR-10a and Anti-miR-196a on HOXD Gene Expression in Breast Cancer Cells

This study investigates the effects of Anti-miR-10a and Anti-miR-196a on the expression of HOXD family genes (HOXD3, HOXD4, HOXD8) in breast cancer cell lines MCF7 and MDA-MB-231. We assessed the relative expression levels of these target genes following treatment with miRNA inhibitors. Quantitative analysis revealed significant changes in HOXD gene expression, highlighting the potential regulatory role of these miRNAs in breast cancer progression. Understanding these interactions could inform therapeutic strategies for targeting miRNA pathways in cancer.

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Impact of Anti-miR-10a and Anti-miR-196a on HOXD Gene Expression in Breast Cancer Cells

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  1. a Relative hoxd4 expression Anti-miR-196a 3.0 N.C. Anti-miR-10a 2.4 * 1.8 1.2 * * 0.6 0 MCF7 MDA-MB-231 hoxd8 hoxd3 hoxd4 β-actin hoxd4 β-actin b e Cont dme-miR-10 hre-miR-10a mmu-miR-10a hsa-miR-10a hsa-miR-10b gga-miR-10b c Relative miR-10a/b expression 5 miR-10a 4 miR-10b f hoxd8 3 hoxd3 MCF7 2 hoxd4 β-actin 1 0 MDA- MB-231 1 4 2 3 5 6 Relative hoxb/d4 expression d Anti- miR-10a Cont N.C. 8 hoxd4 hoxb4 g 6 4 N.C. Anti- miR-196a Anti- miR-10a 2 0 1 4 2 3 5 6

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