FIBROMYALGIA. FIBROMYALGIA. 1 ST defined by ACR criteria1990
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Aggressive regimes have long replaced the old treatment paradigm of 6 months NSAIDs then cautious introduction of DMARDs
NICE recommend combination therapy from the beginning, including steroids
BNF outdated as says drugs are contraindicated together due to potential drug interactions
Preference for 2 DMARDs with steroid initially, trying to phase out steroids over several months, but patients often resistant to such initial polypharmacy
best response when used with MTX (or another DMARD) but all but infliximab can be used alone
affinity and thus inhibits the co-stimulation of T cells