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Calsulin in the management of Type 1 Diabetes - PowerPoint PPT Presentation


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Calsulin in the management of Type 1 Diabetes. Background. Today intensive insulin therapy is the gold standard for therapy in patients with type 1 diabetes. Blood glucose levels. Intake of CHO. Physical exercise. Insulin dose. Background.

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Presentation Transcript
slide2

Background

Today intensive insulin therapy is the gold standard for therapy in patients with type 1 diabetes

Blood glucose levels

Intake of CHO

Physical exercise

Insulin dose

slide3

Background

  • Calsulin is a simple tool developed for the establishment of insulin dose taken into account the following parameters:
  • Blood glucose levels
  • Intake of carbohydrates
  • Intensity of physical exercise
slide4

Aim and design of the study

  • The present project aims to demonstrate the efficacy of Calsulin in improving metabolic control as assessed by HbA1c in patients with type 1 diabetes undergoing intensive insulin therapy.
  • Inclusion criteria:
  • 40 patients affected by type 1 diabetes
  • Age range: 18-65 years
  • Disease duration > 1 year

Exclusion criteria:

  • Insulin requirement (I.R.) > 1.2 IU/Kg/die
slide5

Methods

  • Patients was randomized 1:1 and followed-up with visits every 3 months
  • HbA1c and daily insulin requirement was evaluated at 0 and 3 months
  • Statistical analysis: Paired t test (two tailed) was used to analyze the

differences of HbA1c and daily insulin requirement between two groups

slide6

Clinical features

(data are mean  SD)

slide7

Results at 3 months

(data are mean  SD)

slide8

Results at 3 months

(data are mean  SD)

slide9

Results at 3 months

HbA1c (%)

I.R.(IU/Kg/die)

slide10

Conclusion

Data showed an improvement in the HbA1c at 3 months in the Calsulin treated group, however the result wasn’t statistically significant analyzing the differences of HbA1c in the two groups

Calsulin is an acceptable and practical tool to manage insulin dose and it can improve the overall metabolic control, as shown by a reduction of HbA1c

Disadvantages: display not clear, difficult to quantify physical exercise and to choose adeguate insulin ratio