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Epstein-Barr Virus

Epstein-Barr Virus. Brittany Seyler. What is it?. Herpes virus that infects B Cells and Epithelial cells- linked to malignancies in both Responsible for Infectious Mononucleosis 2nd most common. Background. Named after  M. Anthony Epstein  and  Yvonne Barr in 1961

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Epstein-Barr Virus

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  1. Epstein-Barr Virus Brittany Seyler

  2. What is it? • Herpes virus that infects B Cells and Epithelial cells- linked to malignancies in both • Responsible for Infectious Mononucleosis • 2nd most common

  3. Background • Named after M. Anthony Epstein and Yvonne Barr in 1961 • Humans are the only known reservoir

  4. Transmission • Saliva • Blood transfusions • Infects 95% of the world’s population • 90% of US population infected by age 25

  5. Symptoms • Fever • Fatigue • Sore throat • Swollen lymph glands • Weight Loss • Vomiting • Hemolysis

  6. Demographics • Occurs worldwide • No racial predilection • Occurs earlier in females than males

  7. Structure • Crystal structure • Linear, double stranded DNA • “spikes” • Viral envelope easily damaged • Toroidal shaped core

  8. Each Line Plot represents different antigens to the EBV over the incubation period of the virus as a whole. • This scaling can be used in the testing of carriers, and previous carriers of the EBV Representation Of Immuno response vs viral incubation.

  9. Viral Detail • Family:Herpesviridae • Subfamily:Gammaherpesvirinae • Genus:Lymphocryptovirus • Species:Human herpesvirus 4 (HHV-4) • Associated with several forms of cancer, lymphoma in HIV patients, and believed to be associated with higher risks of autoimmune conditions in those affected.

  10. Prevention

  11. http://www.cdc.gov/ncidod/diseases/ebv.htm http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001617/ http://emedicine.medscape.com/article/963894-overview http://www.pnas.org/content http://www.nature.com/nsmb/journal http://virus.stanford.edu/herpes/transmission.html http://bioweb.uwlax.edu Sources

  12. Thank You :)

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