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Possible fam hx of AD no psych hx slow progression of sxs long sx duration no complaints of deficits vague complaints conceals deficits variable emotional reaction decreased awareness of deficits behavior congruent. Fam hx of MD prev psych hx rapid progression of sxs

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AD compared to DSD


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ad compared to dsd
Possible fam hx of AD

no psych hx

slow progression of sxs

long sx duration

no complaints of deficits

vague complaints

conceals deficits

variable emotional reaction

decreased awareness of deficits

behavior congruent

Fam hx of MD

prev psych hx

rapid progression of sxs

short sx duration

complains of deficits

complains in detail

emphasizes complaints

distressed

aware of deficits

behavior incongruent

AD compared to DSD
ad compared to dsd1
relies on notes, calendars, etc

mood environmentally responsive

night confusion

variable early am awakening

topographical disorientation

temporal disorientation

dress apraxia

variable loss of libido

does not try to keep up

persistent mood disorder

variable night confusion

early am awakening

topographically oriented

fluctuating temporal disorientation

no dress apraxia

severe loss of libido

AD compared to DSD
ad versus pdp on np testing
Poor free verbal recall

flat learning curve

no primacy effect

impaired recency effect

frequent extra-list errors

few “don’t know” errors

perseverative errors

Impaired recog memory

false positives

semantic organization unhelpful

prompting unhelpful

Variable free verbal recall

reduced U learning curve

reduced primacy effect

reduced recency effect

infrequent extra-list errors

“don’t know” errors

few perseverative errors

Intact recog memory

few/no false positives

semantic organization helpful

prompting helpful

AD versus PDP on NP testing
ad versus pdp on np testing1
Good effort on tasks

impaired on “automatic” encoding

impaired on “effortful” encoding

consistent perform across tasks of similar difficulty

memory performance worse than complaints

rapid rate of forgetting

need frequent reminders of task directions

Poor effort on tasks

intact on “automatic” encoding

impaired at “effortful” encoding

variable performance across tasks of similar difficulty

memory performance better than complaints

normal rate of forgetting

remembers task directions

AD versus PDP on NP testing
ad vs dsd on neurophysiological measures
bilateral temporoparietal hypometabolism (PET)

bilateral temporoparietal hypoperfusion (SPECT)

cortical atrophy (MRI)

enlarged sulci (MRI)

decreased density in white matter

abnormal EEG

bilateral frontal lobe hypometabolism (PET)

bilateral frontal lobe hypoperfusion (SPECT)

white matter hyperintensities (MRI)

basal ganglia

periventricular area

normal EEG

Ad vs DSD on Neurophysiological measures