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This supplemental figure presents individual and pooled median overall survival rates with corresponding confidence intervals in study arms based on different treatment patterns. Hazard ratios are also included, aiding in the evaluation of CCT-, CCCT, and SCCT. The data highlights the impact of various treatments on median overall survival duration in months.
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Supplemental Figure 3. Individual and pooled median overall survivals with corresponding 95% confidence interval in study arms, according to the patterns of CCT: CCT-, CCCT and SCCT. Hazard ratios of CCCT/SCCT to CCT are shown at the bottom of the figure. Median overall survival (months) 0 10 20 30 40 50 n=32 Bonner, 1998 (arm C) Komaki, 1997 (arm 2) n=82 Kubota, 2000 n=74 Lee SW, 2003 n=161 Curran, 2011 (arm 3) n=200 Furuse, 1995 n=65 Ichinose, 2004 n=70 n=156 Furuse, 1999 Curran, 2011 (arm 2) n=200 CCT- Kim, 2005 n=135 Lee, 1996 n=79 Yoshizawa, 2003 n=30 Fukuda, 2007 n=48 Bradley, 2010 n=44 n=42 Kiura, 2003 Segawa, 2010 n=100 n=41 Jeremic, 1998 Segawa, 2010 n=100 Jeremic, 2005 n=64 n=49 Cho, 2009 Total n=1,772 17.9(95%CI: 16.1-19.9) Jain, 2009 n=67 Byhardt, 1995 n=42 Le Péchoux, 1996 n=34 Choy, 2000 n=43 Ratanatharathorn, 2001 n=30 Rusu, 2007 n=57 Albain, 2002 n=50 Park, 2003 n=54 Belani, 2005 (arm 3) n=92 CCCT Lau, 2001 n=34 Segawa, 2000 n=50 Iwasaki, 2006 n=46 Yamamoto, 2010 (arm B) n=152 Yamamoto, 2010 (arm A) n=153 Choy, 1998 n=40 Govindan, 2011 (arm A) n=48 CCT+ Yamamoto, 2010 (arm C) n=156 Albain, 2009 (arm 2) n=194 Sakai, 2004 n=33 Ohyanagi, 2009 n=50 Oshita, 2010 n=35 19.1 (95%CI: 17.2-21.2) Total n=1,460 Bastos, 2010 n=32 Fournel, 2005 n=100 SCCT Mostafa, 2007 n=32 Gandara, 2003 n=83 19.0 (95%CI: 14.6-24.7) Total n=247 Hazard ratio of CCCT to CCT- = 0.94 (95%CI: 0.81-1.09), p= 0.424 Hazard ratio of SCCT to CCT- = 0.94 (95%CI: 0.71-1.26), p= 0.694
