Interferences - are some methods better than others?. Graham Jones Department of Chemical Pathology St Vincent’s Hospital, Sydney. Contents. Background Choosing your instrument Using your instrument. Introduction.
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Department of Chemical Pathology
St Vincent’s Hospital, Sydney
The visible interferences
Final/original result x 100 (%)
Haemolysate added (as haemoglobin. mg/dL)
Roche Modular <P>
Haemolysate added to patient samples and concentrations measured
Using RCPA-AACB Allowable Limits of Performance
Examples of tests where different instruments show wide variations in response to haemolysis (Data from 2000).
Olympus Cholesterol Reagent and Modular Cholesterol Reagent
2.5, 4.1 and 6.0 mmol/L
10% at 700
Response best expressed as absolute (not not percentage)
Unhappier ptns and Drs
Fewer clinical errors
More clinical errors
A supplier’s question…