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By Dr Xanya Sofra-Weiss

Signaling Energy Revolutionizes Anti-Aging Presenting two Experimental Studies on the Ion Magnum. By Dr Xanya Sofra-Weiss.

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By Dr Xanya Sofra-Weiss

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  1. Signaling Energy Revolutionizes Anti-AgingPresenting two Experimental Studies on the Ion Magnum By Dr Xanya Sofra-Weiss

  2. Signaling Technology views aging and desease as the result of faded ormissing signals that would otherwise give the instructions for the adequatesynthesis of hormones, antibodies, enzymes and other proteins such ascollagen, elastin, hemoglobin, actin, myosin, ATPace, etc

  3. The proteins in each cell receive a complex combination of signals which simultaneously trigger many different signaling pathways which provide an opportunity for cross-talk between different signals. The cell integrates information from many different signaling pathways to initiate an appropriate response. Missing signals leave the cell with incoherent instructions hence leading to an inappropriate response that may be deleterious to the cell.

  4. Aging and Disease • Aging is the result of deteriorated protein signals leaving the body with multiple deficiencies in terms of hormones, antibodies, enzymes and other proteins such as collagen, elastin, hemoglobin, actin, myosin, ATPace, etc • Cancer is not the result of a number of “rebel” cells that refuse to follow the rules of cellular proliferation and differentiation but a number of “obedient” cells who got the wrong instructions as a result of Singaling deficiency

  5. Some of the Functions of Proteins • enzymatic catalysts • DNA repair • transport molecules (hemoglobin transports oxygen) • storage molecules • they are used in movement --proteins are the major component of muscles • needed for mechanical support (collagen) • mediate cell migrations • antibody proteins are needed for immune protection • control of growth and cell differentiation uses proteins • Collagen, Elastin are Proteins along with about 100,000 more types of Proteins that exist in the human body

  6. Among 4,087 different proteins identified with highconfidence by massspectrometry from 2,357 successful purifications, our core dataset(median precision of 0.69)comprises 7,123 proteinto protein interactions. Investigating how such signaling pathways are organized is relevant not only for understanding how normal cells work, but also for appreciating the molecular basis for aging and disease, since aging as well as many human disorders result from breakdowns in signal transduction

  7. Result of examing these comprises 7,123 protein to protein interactions in aged vsyoung subjects demonstrated that Aging is the result of the disorganization in the interactions or communications between Protein to Protein interactions

  8. Contrast of Pixel Intensities Several studies have indicated an alteration in signal transduction with ageing. Eg. T cells from aged have decreased membrane fluidity. T cells activation and proliferation is decreased as a result of decreased recruitment of signaling proteins associated with the initial complex of signal transduction

  9. Diminished protein signals from the Champeroneproteins during protein synthesis leads to decreased synthesis of proteins and a subsequent deficiency in the aged.

  10. EXAMPLES:Less collagen and elastin (wrinkles);Less actin and myosin (sagging muscles); Less hormones (weight gain from decreased TSH, T3, muscular hypotrophy from decreased IGF-1) Less Atpace leading to decreased ATP synthesis, etc Zhang et al (2002) showed that that human age-related cataract is associated with decreased expression of L21 and other ribosomal proteins.

  11. Insulin Signaling Ziv et al (2011) Mutations of genes involved in the insulin/insulin-like growth factor-1 (IGF-1) signaling pathway affect lifespan in several model organisms. decreased IGF-1 receptor levels due to a single gene knockout have been demonstrated to have increased lifespan.

  12. Bartke (2011) Longevity is associated to insulin signaling and specifically to reduced insulin levels and enhanced sensitivity to insulin. • Insulin signaling alters gene expression in the pancreas and in different insulin/IGF-1 target organs (e.g. muscle, liver, heart), and results in a slowing of the aging process.

  13. Insulin Code

  14. Stem Cells Need Specific SignalsFor Correct Differentiation Researchers from Johns Hopkins have discovered the presence of functional ion channels (that act like electrical wires) in human embryonic stem cells (ESCs). Li's lab (John Hopkins University) genetically engineered heart cells derived from human ESCs, suggesting the possibility of transplanting unlimited supplies of healthy, specialized cells into damaged organs. A major concern for human ESC-based therapies is the potential for engineered grafts to go haywire after transplantation and form tumors... “We therefore decided to explore the existence of ION CHANNELS in pluripotent, or versatile, human ESCs because ELECTRICAL ACTIVITY IS KNOWN TO REGULATE CELL DIFFERENTIATION AND PROLIFERATION," says Li.

  15. Jan van Deursen (2002 -2011) studied study a protein called BubR1, which helps ensure that each cell has the correct number of chromosomes during cell division They found that a deficiency in protein BubR1 causes premature aging. They also found that BubR1 decreases with age. Decreased BubR1 also correlated with abnormal chromosome numbers in sperm and eggs, associating this protein with infertility. It is also associated with cataracts, heart desease and other age related diseases.

  16. AGING iS THE RESULT OF INCREASINGIMBALANCES AS A RESULT OF: 1. Decreased Number of Proteins. Underneath that there is a2 . A decrease in the Champerone proteins that help in the protein folding.3. A decrease or the absence of signals initiating and completing the process of protein synthesis

  17. What can go wrong in terms of Signaling • 2011: Examination of a mechanism involving the protein stromal-derived factor-1 (SDF1), and its receptor CXCR4 provides proof that cancer is the result of cells getting the wrong signals giving them the wrong instructions. • A DNA mutation while it is unfolding to copy itself during division or a mutation anywhere in the signaling pathways of theseries of proteins carrying the DNA info means that the wrong order is sent.

  18. Even when the right one arrives, our cellular copiers can make mistakes, leading to new genes that bark out the wrong orders.Fortunately, our bodies have patrols that constantly neutralize most genetic mistakes, but get enough of them and cancer develops.

  19. SINGALING TECHNOLOGY: 1. IDENTIFY THE SIGNALS THAT REINSTATE THE SYNTHESIS OF KEY PROTEINS ( research started in Cambridge University) 2. INDENTIFY THE SIGNALS OF PROTEIN INTERACTIONS DURING IMPORTANT BIOLOGICAL FUNCTIONS SUCH AS CELLULAR PROLIFERATION AND DIFFERENTIATION CONCEPTUALIZE SUCH PROTEIN INTERACTIONS AS A DYNAMIC PROCESS LIKE THE NOTES OF A MUSICAL PIECE OR THE IMAGES FORMING A MOVING PICTURE

  20. Signaling Energy Amplifies or substitutes protein (antibodies, hormones, enzymes, etc) signaling that has diminished or paused with age leading to a revival of endogenous protein synthesis, energy production while acting as a MEGAANTI-OXIDANT

  21. Fate and behavior of Cells is controlled by signaling pathways which deliver information from 1. Protein signals in surrounding tissue 2. Proteins signals emitted by other cells. Proteins and their signals are transported by microtubules

  22. We have been researching the aging process ofhealthy individuals with a device built in Cambridgeon the basis of specifications that were researched in Cambridge by comparing the signaling propertiesof young vs aged cells and by artificially sendingthe signals derived from a colony of young cells toa colony of old cells and seeing it this “transfer” of signals from the young to the old with in any way alterthe signaling pathways of the signaling propertiesof the old colony of cells.

  23. Results have shown a significant increase in a number of proteins: Collagen Increase by 62% Actin Increase by 45% Myosyn Increase by 38% Hemoglobin Increase by 76% ATPace Increase by 80% Testosterone Increase by 46% IGF-1 Increase by 62% Insuline Increase by 23% BubR1 by 18% Cyclic Amp by 63% G Proteins by 57% Sitruins by 45%

  24. Clinical Studies Results have revealed the visibly dramatic results that persist from five to nine months with at least three treatments

  25. How are these waveforms composed? First we record the signals of interacting cells by cell recording methods that focus on cellular interactions, using advanced computer software that were developed specifically for that reason. Then we go through thousands of combinations of signals to recompose the biological decoded signals

  26. THE IMPORTANCE OF TIMING Combining the signalsis like editing a movieor composing a symphony Timing is Crucial

  27. FACIAL REJUVENATION RESULTS

  28. THANK YOU FOR YOUR KIND ATTENTION THANK YOU FOR YOUR KIND ATTENTION

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