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Lipidne mikrodomene - rafti

Lipidne mikrodomene - rafti. Karolina Ivičak. Glavne lipidne strukture v raftih. Simons, K. and Toomre, D. (2000): Lipid rafts and signal transduction. Nat. Rev. Mol. Cell Biol. 1, 31-40. Fosfolipidi: fosfatidil etanolamin , fosfatidil serin , fosfatidil holin , fosfatidil inositol

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Lipidne mikrodomene - rafti

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  1. Lipidne mikrodomene - rafti Karolina Ivičak

  2. Glavne lipidne strukture v raftih Simons, K. and Toomre, D. (2000): Lipid rafts and signal transduction. Nat. Rev. Mol. Cell Biol. 1, 31-40. • Fosfolipidi: fosfatidiletanolamin, fosfatidilserin, fosfatidilholin, fosfatidilinositol • Sfingolipidi: ceramidi (H), sfingomielini (fosfoholin), glikosfingolipidi (sladkor)

  3. Proteini v lipidnih raftih • proteini, ki imajo GPI-sidra (glikozilfosfatidilinozitol) • transmembranski proteini • dvojno acilirani proteini – tirozinske kinaze iz družine Src • kaveolin –tvori caveolo, ki je specifičen tip mikrodomene Simons, K., Ikonen, E. (1997): Functional rafts in cell membranes. Nature, 569-572.

  4. Organizacija v lipidnih raftih PC - fosfatidilholin SM - sfingomielin Model lipidnega rafta v trans Golgi mreži Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., Walter, P. Figure 13-63. Molecular Biology of theCell 4th ed.,New York and London: Garland Science (2002). Sprong, H., van der Sluijs, P. and van Meer, G. (2001): How proteins move lipids and lipids move proteins. Nat. Rev. Mol. Cell Biol. 2, 504-513.

  5. Lipidni rafti – v detergentih netopni kompleksi Lipidni rafti ostanejo netopni pri nizkih T po tretiranju z: • Triton X-100 (neionski detergent) • Brij-98 (neionski detergent) • CHAPS Lipidni rafti so topni v: • oktilglukozidu • zgoraj omenjenih detergentih pri višjih T

  6. Funkcije lipidnih raftov • Prenos signalov • Prenos in sortiranje proteinov in lipidov • Endocitoza – neodvisna od klatrina: • potocitoza – preko kaveol • od kaveolina neodvisna endocitoza

  7. Prenos signalov Simons, K. and Toomre, D. (2000): Lipid rafts and signal transduction. Nat. Rev. Mol. Cell Biol. 1, 31-40.

  8. Prenos signalov Simons, K. and Toomre, D. (2000): Lipid rafts and signal transduction. Nat. Rev. Mol. Cell Biol. 1, 31-40.

  9. Prenos in sortiranje proteinov in lipidov Lodish, H., Berk, A., Zipursky, S. L., Matsudaira, P., Baltimore, D., Darnell, J. E. Figure 17-43.Molecular Cell Biology. 4th ed., New York: W. H. Freeman & Co (2000)

  10. Potocitoza in od kaveolina neodvisna endocitoza Sprong, H., van der Sluijs, P. and van Meer, G. (2001): How proteins move lipids and lipids move proteins. Nat. Rev. Mol. Cell Biol. 2, 504-513.

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