1 / 1

Effects of Bim-/- on Treg and Tcon Viability and Proliferation in IL-2, IL-4, and IL-7 Environments

This study investigates the impact of Bim-/- deletion on the viability and proliferation of regulatory T cells (Treg) and conventional T cells (Tcon). We analyze the response of both T cell subsets in the presence of IL-2, IL-4, and IL-7, assessing CD25 and Foxp3 expression levels. Results highlight that Bim-/- Tcon and Treg exhibit distinct viability and proliferation patterns, emphasizing the critical role of Bim in T cell dynamics. Statistical analyses confirm significant differences, providing insights into the mechanisms regulating T cell responses.

kaden
Download Presentation

Effects of Bim-/- on Treg and Tcon Viability and Proliferation in IL-2, IL-4, and IL-7 Environments

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. 2.5 16.5 2.3 5.3 2.9 2.4 24 71 4.6 23.4 18 9.4 13.4 13.9 12 23 6 WT Tcon WT Treg +- +IL2 +IL4 +IL7 76 WT Bim-/- *** 30 100 % CD25+Foxp3+ (in CD4+ cells) Count 80 20 Bim-/- Tcon Bim-/-Treg 60 Viability(%) 10 40 20 BIM-/- Tcon BIM-/- Treg WT Tcon 0 WT Treg *** P = 0.0001 CFSE 0 WT Tcon WT Treg WT Tcon WT Treg WT Treg+IL7 8 22 10 Foxp3 PI Bim-/- Tcon Bim-/-Treg Bim-/- Tcon Bim-/-Treg Bim-/- Treg+IL7 53 FSC CFSE a b B6 CD45.1 Bcltg-CD45.1 BALB/C B6 Bim -/- Foxp3 Foxp3 CD4 CD4 B6 Bim -/- CD45.1 Bcltg-CD45.1 B6 BALB/C Foxp3 Foxp3 CD25 CD25 d e c g f

More Related