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VIEW. GENERATE. VIEW. 17.6 s. 26.4 s. 26.4 s.

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  1. VIEW GENERATE VIEW 17.6 s 26.4 s 26.4 s An fMRI Investigation of Sentence Generation Attempts by Chronic Non-fluent AphasicsK.M. McGregor1, K.D. White1, A.B. Moore1 , L. M. Maher2,3, K.K. Peck1, C. E. Wierenga1, K. Gopinath1, M. Kurtzman1, M.Gaeifsky1, A. Wabnitz1, M. Benjamin1, D. A. Soltysik1 , R. Briggs1, B. Crosson1 1Malcom Randall VA RR&D Brain Rehabilitation Research Center and University of Florida, Gainesville, Florida2Baylor College of Medicine, 3Houston VA Center of Excellence on Healthy Aging with DisabilitiesThis poster is available on the Web at www.BIRC.phhp.ufl.edu s01 s02 Background Methods Results: Behavioral Performance • fMRI at 3T using a sentence generation task • Pre-scanning task performance assessments on sentence generation • fMRI task: silent sentence generation describing events in simple line drawings • Baseline task: passive viewing of nonsense objects • (e.g.) • Runs: 5 runs with 5 active blocks (26.4 seconds) with a variable baseline interval (17.6 s, 22 s, or 26.4 s). Run order randomized between subjects • fMRI Analysis Procedures: • Individual subject (patients & controls): • Deconvolution (AFNI) with R2 > 0.16 as statistical threshold • Voxel cluster analysis with contiguity threshold of > 100 μL with a 1.8mm voxel radius • Group analysis (controls): • Area under the curve w/ spatial smoothing on 5mm FWHM kernel • t-test: sentence generation against baseline (p<.005); • Voxel cluster analysis with contiguity threshold of > 100 μL • Agrammatism: a disruption in grammatical functions supporting language common in nonfluent aphasia • Syntactic language generation has received little attention in fMRI particularly with respect to rehabilitiation of nonfluent aphasia Results: Imaging Participants s01 s02 Control s03 s04 Red indicates p < 0.005; yellow indicates p< 0.001. Conclusions • Homologues to left lateralized areas implicated in syntactic language production in controls are indicated as active in similar tasks in agrammatic aphasics • Previous findings of right lateralized inferior frontal (Naeser et al., 2004) and posterior perisylvian activation (Vandenbulcke et al., 2005) in patients exhibiting poor performance on language tasks are supported by this investigation • Question: Does the activity in right posterior perisylvian regions and right inferior frontal areas reflect neural processes that are critical or detrimental to rehabilitation of syntactic language production? • Question: Does the left frontal activity outside the inferior frontal gyrus facilitate or interfere with sentence production tasks? s03 s04 • Control: Four healthy adults (Ages: 41, 46, 52, 58) This research was supported by NIH grants P50-DC03888, R01-DC03455 and the Gainesville Brain Rehabilitation Research & Development Center.

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