1 / 3

Structures of the lipids used for the intracellular redox and ultrasound triggered release :

Ultrasound-enhanced triggered release from echogenic liposomes Sanku Mallik, North Dakota State University Fargo, DMR 1005011.

julius
Download Presentation

Structures of the lipids used for the intracellular redox and ultrasound triggered release :

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Ultrasound-enhanced triggered release from echogenic liposomesSanku Mallik, North Dakota State University Fargo, DMR 1005011 We have prepared echogenic liposomes which are programmed to release the encapsulated contents in the extracellular media triggered by extracellular, metastasis-causing enzymes. The rate and amount of contents release are enhanced by the application of diagnostic frequency ultrasound. By altering the lipids in the liposomes, we have prepared echogenic liposomes which release the encapsulated anticancer drug Doxorubicin within cancer cells in response to increased glutathione concentration or decreased pH. The release from these liposomes are also enhanced by the application of diagnostic frequency ultrasound.

  2. Ultrasound-enhanced triggered release from echogenic liposomesSanku Mallik, North Dakota State University Fargo, DMR 1005011 A Native American female student (Jessica Tautzaeur. McNair Scholar) is currently working on the project. She is trained on the preparation of liposomes, and their characterization employing a variety of analytical techniques. We are currently writing a manuscript with Jessica as a coauthor. An under-represented high-school student (Rawat Hossain) worked on this project during the summer months. Rawat is a coauthor on another manuscript (under preparation). Mallik has introduced a Graduate-level course (Advanced Bio-Organic Chemistry) to discuss various triggered release strategies reported in the literature. This is a summer class (offered in 2010 and in 2012). The results obtained with this award were also discussed in this class.

  3. Ultrasound-enhanced triggered release from echogenic liposomesSanku Mallik, North Dakota State University Fargo, DMR 1005011 Structures of the lipids used for the extracellular triggered release of contents with matrix metalloproteinases and ultrasound: CH3(CH2)16CONH–GPQGIAGQR(GPO)4GG (30 mol%) 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC, 70 mol%) Structures of the lipids used for the intracellular redox and ultrasound triggered release: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC, 70 mol%)

More Related