1QQ# 13 for 10:30. Why is action potential conduction velocity slower in a non-myelinated axon compared to a myelinated axon? In what ways do voltage-gated Na+ channels differ from voltage-gated K+ channels?. 1QQ# 13 for 11:30.
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Most neurotransmitters are synthesized in the axon terminal.
Exceptions: Peptide NTs originate in cell body, move in vesicles by fast orthograde axonal transport to axon terminal.
Vesicle release proportional to Ca++ influx (High f AP leads to residual Ca++ in terminal)
Tetanus toxin & Botulinum toxin disrupt SNARE function.
= ACH = Acetylcholine
Agonist = Nicotine
Agonist = Muscarine
Antagonist = Curare
Antagonist = Atropine
Types of Acetylcholine Receptors so named for agonist:
Nicotinic AChR and Muscarinic AChR
Priority by proximity
To axon hillock!
Summation and Synaptic Integration
Challenge question: Suppose each IPSP hyperpolarizes by 5 mV and each EPSP depolarizes by 5 mV.
If 4 inhibitory synapses are active at the same time, how many excitatory synapses must be active simultaneously to exceed threshold (-55 mV) if the resting membrane potential is -70mV?
Synapses named for NT used: -ergic