Randy Gollub, MD,PhD

1. Overview of the Harvard Catalyst Imaging program- how to use the resources for your research Randy Gollub, MD,PhD May 19, 2009 http://catalyst.harvard.edu

2. Harvard Catalyst: The History and the Basics GCRC program (20+ yr NCRR/NIH funded clinical research support program) discontinued MGH Biomedical Imaging Core established 2002 CTSA 2007(Roadmap initiative) HU- Response-Harvard Catalyst (PI Lee Nadler/Co-Director: Steve Freedman) We are a pan-Harvard enterprise dedicated to improving human health by: Creating Connections Enabling research At the Cutting Edge of discovery Nurturing clinical and translational researchers 1

3. Imaging Consortium History • MGH and BWH GCRC Imaging Cores NCRR • MGH and BWH P41s devoted to medical imaging • Martinos Center for Functional Imaging Technologies (Rosen) • Neuroimage Analysis Center (Kikinis) • Image Guided Therapy (Jolesz) • Biomedical Informatics Research Network (BIRN) • Morphometry Testbed (Rosen) • Functional Neuroimaging Testbed NIH NCBC • National Alliance for Medical Image Computing (NA-MIC) Fee for Service (MGH/BWH/DFCC) • DFCI Tumor Metrics Core

4. Institutions participating in Harvard CTSC Yearly budget: $38 million (23 NIH + 15 matching) Academic Healthcare Centers • Beth Israel-Deaconess Medical Center • Brigham and Women’s Hospital • Massachusetts General Hospital • Children’s Hospital Boston Specialty Hospitals and Institutes • Dana-Farber Cancer Institute • Forsyth Dental Institute • Joslin Diabetes Center • Massachusetts Eye and Ear Infirmary • McLean Hospital • Schepens Eye Research Institute Massachusetts Institutes of Technology Harvard University • Faculty of Arts and Sciences • Harvard Business School • Harvard School of Dental Medicine • Harvard Divinity School • Graduate School of Design • Graduate School of Education • Kennedy School of Government • Harvard Law School • Harvard Medical School • Harvard School of Public Health • Harvard School of Engineering Community Healthcare Institutions • Cambridge Health Alliance • HMS Department of Ambulatory Care and Prevention at Harvard Pilgrim Healthcare 3 Blue –Imaging Consortium

5. Harvard Catalyst • Programs (Selected list) • Translational Technologies (Imaging & Genetics) • Participant and Clinical Interactions Resource (PCIR) • Development of Novel C/T Methodologies • Biomedical Informatics • Pilot studies • Design and Biostatistics (Mark Vangel) • Research Education, Career Development • Diversity and Health Disparities Research • Ethics • Linkages across the institutions • Regulatory Knowledge and Support

6. Imaging Consortium Team 5

7. Mission of the Imaging Consortium Expand imaging in clinical research: Build & deploy infrastructure (expertise in single and cross site image acquisition, image analysis, visualization & data management software tools) Provide expert consultation in the use of imaging for clinical translational research Educate and advise about available imaging and image processing capabilities in the Harvard environment Provide leadership & education at the local and national level 6

8. Harvard Catalyst website http://catalyst.harvard.edu/home.html 7

9. Image Consortium Consultation Service 8

10. Image Consortium Consultation Service 9

11. Technologies and Expertise Cancer imaging, MRI, PET, CT, fMRI, US, pediatric imaging, neuroimaging. Focused on assisting with planning and design of research proposals and/or methods for image analysis. Consultation is available for the preparation of a grant or IRB submission. We do not (yet) provide ongoing support for the implementation of new studies or the analysis of data from existing studies. 10

12. Example of Imaging Consultation Optical Imaging of Cerebral Oxygenation in Infants (MGH) • Study of brain-development in premature infants (new collaboration: CHB-BWH-MGH) CHB: new Fetal-Neonatal Neuroimaging and Developmental Science Center Slicer (BWH): quantitative tractography (Gilmore, 2007 AJNR) 11

13. Pilot funds • Eligibility:All Harvard faculty are eligible to apply, regardless of degree or institutional affiliation. • First round: 62 projects funded (out of 602) • Funds:Pilot Grants will be awarded in the amount of $50,000, with an award period of one year. (80 grants expected) • Deadlines:Letter of intent: May 13, 2009 Full application: June 12, 2009 • Contact:Harvard Catalyst Research Navigators617 432-7800

14. MGH Biomedical Imaging Core 13

15. MGH Biomedical Imaging Corehttp://www2.massgeneral.org/crc/bic/index.htm 14

16. MGH Biomedical Imaging Corehttp://www2.massgeneral.org/crc/bic/index.htm 15

17. MGH Biomedical Imaging Corehttp://www2.massgeneral.org/crc/bic/index.htm 16

18. MGH Biomedical Imaging Core TMS 17

19. MGH Biomedical Imaging Corehttp://www2.massgeneral.org/crc/bic/index.htm 18

20. MGH BIC Imaging Engineers Deployed cross site calibrated physiologic monitoring systems for MRI at BWH, Children’s, BIDMC, Harvard FAS and MIT Catalyst created a community of biomedical engineers w/ a shared focus on supporting C/T imaging 19

21. MGH Biomedical Imaging Corehttp://www2.massgeneral.org/crc/bic/index.htm 20

22. MGH Biomedical Imaging Corehttp://www2.massgeneral.org/crc/bic/index.htm 21

23. MGH Biomedical Imaging Core 22

24. MGH Biomedical Imaging CoreComing in July 2009!Webform PCIR application 23

25. Medical Imaging Informatics Examples: Clinical: Ruling out appendicitis based on CT scans. Are there metrics that can be found by analyzing clinical data? Quantitative output from Freesurfer for Alzheimer disease Research: Helping TIMC get easier access to PACS system for clinical trials 24

26. Medical Imaging Informatics Secondary Use of Clinical Imaging Data (Integration with i2b2) Desikan et al, Brain in press Standard T1 MRI scan AUC 0.95 (specificity 91%, sensitivity 90% to discriminate MCI from age matched controls 25

27. Medical Imaging Informatics IT Catalyst infrastructure: i2b2: scalable computational framework to help translation of genomic findings. BIRN: XNAT imaging informatics platform: large collections of images and study-specific metadata to be managed by image-driven clinical translational research groups. NA-MIC:robust, open source solutions for medical image analysis, visualization and management software tools by the creation of a “desktop” version of XNAT. Key image analysis software tools: Slicer, Freesurfer. 26

28. Medical Imaging Informatics XNAT Enterprise Dr Y Desktop Alzheimer Dr Z Desktop Chronic pain management Dr X Desktop Pediatric rare disease Dr W Desktop Quantitative cancer biomarkers PACS PACS Annotating Genomic Data #2 Project Management File Repository De - Identification Of data Ontology Management Identity Management Natural Language Processing Data Repository (CRC) Workflow Framework Annotating Genomic Data #1 Correlation Analysis 27 i2b2 HIVE

29. Educational Program • Mission: Provide lectures, tutorials, and educational materials promoting the use of imaging to junior investigators and associated research staff • Tailored lectures: Host on-site and based on discipline (oncology, neuro, cardiology, pediatrics, etc) • Generic imaging modules: Basic principles of imaging, quantitative methods, clinical trial design with imaging endpoints, imaging risks and considerations for informed consent forms • Dissemination: through national networks (CTSA, RSNA, IRAT, SNM) 28

30. National Effort in C/T Research39 AHC/23 states Mayo Clinic Northwestern UC Davis Cornell J.Hopkins Duke Emory U. Wash. U. • 14 Imaging programs-(Dan Sullivan/RSNA) Source: http://www.ctsaweb.org/ • Member of the NCRR Clinical and Translational Science Award (CTSA) Consortium-14 new in 08 29

31. http://catalyst.harvard.edu Image_Consult@catalyst.harvard.edu www.na-mic.org/Wiki/index.php/Collaboration:Harvard_CTSC