실험계획 hTERT cell line에 PAH 노출 후 molecular study (cell count, Viability, Copy number variation등) Leukemia cell line - THP-1 cell line 에서 발굴된 Protein (Prelamin-A/C, Poly [ADP-ribose] polymerase 1)의 mRNA 수준에서 expression study - Western blotting을 이용한 prelamin-A/C, poly [ADP-ribose] polymerase 1 Protein 분석 3. In vivo Zebrafish model - Western blotting을 이용한 LMNA, PARP-1 Protein 분석 - Protein (Prelamin-A/C(LMNA), Poly [ADP-ribose] polymerase 1 (PARP-1))의 mRNA 수준에서 expression study 4. SETBP1 mutation in MDS/MPN Patients
vimentin Vimentin plays a significant role in supporting and anchoring the position of the organelles in the cytosol. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.
talin-1 Talin-1 is a protein that in humans is encoded by the TLN1gene. This gene encodes a cytoskeletal protein which is concentrated in areas of cell-substratum and cell-cell contacts. This protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts.
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