實證醫學競賽. 組別：第 B 組. 訂定 PICO. P: Patient with acute pancreatitis I :Pain control by Morphine C : Demerol O : S phincter of Oddi spasm. 資料庫來源. PubMed Ovid. 搜尋之關鍵字. Acute pancreatitis Morphine Demerol S phincter of Oddi spasm Motality Morbility.
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組別：第 B 組
P: Patient with acute pancreatitis
I :Pain control by Morphine
C : Demerol
O : Sphincter of Oddispasm
Sphincter of Oddispasm
Search: Acute pancreatitis, Morphine, Demerol, Motality, Morbility
Limit : clinical trail
出處：Narcotic Analgesic Effects on the Sphincter of Oddi: A Review of the Data and Therapeutic Implications in Treating Pancreatitis THE AMERICAN JOURNAL OF GASTROENTEROLOGY Vol. 96, No. 4, 2001
究設計： Systemic review of cohort studies
All narcotics increased biliary pressure, but morphine was associated with the largest elevation.
Endoscopic retrograde cholangiopancreatography with direct SO manometry demonstrated that the SO is exquisitely sensitive to all narcotics and that increase in biliary sphincter pressure is seen with higher doses of morphine.
結論：Morphine increase in biliary sphincter pressure
Morphine increase in biliary sphincter pressure
出處：Continuous regional arterial infusion therapy with gabexate
mesilate for severe acute pancreatitis World J Gastroenterol 2008 November 7; 14(41): 6382-6387
18 patients diagnostic criteria for acute pancreatis, 9 patients underwent CRAI
Hospitalization significantly differed between the CRAI and non-CRAI groups, 53.3 ± 7.9 d and 87.4 ± 13.9 d (P values< 0.05)
結論： The present results suggest that CRAI
using gabexate mesilate was effective against acute pancreatis
FOY 可以有效改善acute pancreatic 的愈後