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خلاصه

خلاصه. هورمونهای مشتق از اسید امینه. هورمونهای کاتکل امینها هورمونهای تیروئید هورمونهای انسولین و گلوکاگن. Out line (catechol amines. Introduction Structure Biosynthesis Secretion Regulation Catabolism Biology and cellular Action Disorders. Adrenal medulla Hormones.

josephine-fischer
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خلاصه

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  1. خلاصه

  2. هورمونهای مشتق از اسید امینه • هورمونهای کاتکل امینها • هورمونهای تیروئید • هورمونهای انسولین و گلوکاگن

  3. Out line (catechol amines • Introduction • Structure • Biosynthesis • Secretion • Regulation • Catabolism • Biology and cellular Action • Disorders

  4. Adrenal medulla Hormones • Introduction )Epinephrine,nonepinephrine, dopamin • Secretion

  5. بیوسنتز

  6. Biosynthesis of Catecholamines

  7. Biosynthesis, packaging, release of epinephrine in the adrenal medulla cell

  8. Action • A-adrenergic R(Phentalamine,phenoxybezamine,ergotalkaloids • ß-adrenergicR.(Propanolol,Dichlorisoproternol,pronethalol) • (glycogenesis,gluconeogenesis(Amylase↑) • Relaxation of uterine musculature, T.G to FFA, blood pressure)

  9. Catabolism of catecholamines

  10. خلاصه

  11. Out line (thyroid) • Introduction • Structure • Biosynthesis • Secretion • Regulation • Catabolism • Biology and cellular Action • Disorders

  12. anatomy

  13. Thyroid Hormones T3 T4 Introduction -Hormone effect (Growth and differentiation) -Target tissue -Iodid metabolism RDA(Recommended daily allowance) 250-500µg, 0.1% KI 150-200µg/d absorbtion Metabolic effects Behavior changes ,Cardiac out put, growth, digestive ,Oxygen consumption Hyper and Hypo thyroid -

  14. EXAMPLES OF THYROID DISEASES Hyperthyroidism 1° Hypothyroidism www.hsc.missouri.edu/~daveg/thyroid/thy_dis.html

  15. Thyroglobulin(Biosynthesis) • -Biosynthesis of Thyroglobulin • Concentration of iodide( Perclorates,pertectates, perrahnates Thiocynates , ovabaeine 1-oxidation of I – 2-odination of thyrosine 3-Coupeling(DIT,MIT), T3,T4) • 4-Storage of TG in the Follicular Lumen • 5-pinocytosis ,phagocytosis • 6-Hydrolysis 7-Secretion into blood Main four compound(Tg,TPO,H2o2Iodothroglobolin) 134 Thyrosine Residue(25-35) 4 of them active(5,2553,2567,2746)

  16. بیوسنتز

  17. Secretion of thyroid hormones -Secretion T4(80-90 µg)T3(8µg) rT3(1 µg) -Feedback Function?

  18. Plasma proteins carriers • TBG(70-75%,T4,T3) • TBPA(25-30% T4) • Albumin(5-10%T4,25-30% T3) • 0.04T4,0.4%T3 are free. • Deficiency reported,1/2000) • Pregnancy

  19. Metabolism

  20. Biological and Molecular action • -Introduction • Regulation of Oxygen consumption,Regulation of metabolism Carbohydrate, lipids, Proteins, • Catabolism of Growth factors • Growth and differentiation, Metabolism pathway • Mechanism of the effect • 1-Increase the Na+/K+ATPase pump • 2- binding to nuclear receptor and its effect on the expression of Gene • -Thyroid receptors

  21. Disorders of thyroid hormones • -Hyperthyroid • -Graves disease • -Nodular thyroid disease • -Thyroiditis • -Hypothyroidism • Laboratory Evaluation

  22. EXAMPLES OF THYROID DISEASES Juvenile Hypothyroidism Congenital Hypothyroidism www.hsc.missouri.edu/~daveg/thyroid/thy_dis.html

  23. خلاصه

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