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GRAND CHALLENGE

GRAND CHALLENGE. CHALLENGE-SETTING WORKSHOP. Use the following slides to introduce grand challenge AND WORKSHOP PURPOSE (delete slides as required). WHAT IS GRAND CHALLENGE?.

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GRAND CHALLENGE

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  1. GRAND CHALLENGE CHALLENGE-SETTINGWORKSHOP

  2. Use the following slides to introduce grand challenge AND WORKSHOP PURPOSE (delete slides as required)

  3. WHAT IS GRAND CHALLENGE? • THE MOST AMBITIOUS CANCER RESEARCH INITIATIVE IN THE WORLD - A SERIES OF £20M AWARDS SEEKING INTERNATIONAL, MULTIDISCIPLINARY TEAMS • Grand Challenge awards are designed to overcome significant barriers and so the problems identified should not be able to be quickly solved Answers to Grand Challenges should be transformative for cancer research with a clear line of sight to the clinic

  4. SCIENTIFIC ADVISORY PANEL THE INITIATIVE IS STEWARDED BY A PANEL OF WORLD-LEADING EXPERTS IN RESEARCH, POLICY, HEALTHCARE AND INNOVATION WHO SET THE CHALLENGES AND REVIEW APPLICATIONS PROF NIC JONES University of Manchester Cell biology PROF SUZANNE CORY University of Melbourne Cell biology PROF CHARLIE SWANTON The Francis Crick Institute Clinical/Genetics SIR PAUL NURSE Chair Cell biology/Genetics PROF DAVID HUNTER University of Oxford Cancer epidemiology PROF BRIAN DRUKER OHSU Clinical/Translational PROF ED HARLOW Harvard University Genetics/Cell biology PROF RENÉ BERNARDS NKI Genetics/Cell biology PROF KAREN VOUSDEN The Francis Crick Institute Cell biology PROF DAVID LANE A*STAR  Genetics/Cell biology

  5. 7 CHALLENGES SET IN ROUND 1 BIOLOGICAL MARCOMOLECULES • Deliver biologically active macromolecules to any and all cells in the body PREVENTION VACCINES Develop vaccines to prevent non-viral cancers UNUSUAL PATTERN MUTATIONS • Discover how unusual • patterns of mutation are induced by different cancer-causing events EBV CANCERS Eradicate EBV-induced cancers from the world • LETHAL VS NON-LETHAL • Distinguish between lethal cancers which need treating, and non-lethal cancers that don’t 3D TUMOUR MAPPING • Map the molecular and cellular tumour microenvironment in order to define new targets for therapy and prognosis TARGETING MYC • Develop innovative approaches to target the cancer super-controller MYC

  6. ROUND 1 FUNDED TEAMS ROSETTA team imaxt team STUDYING TUMOUR METABOLISM FROM EVERY ANGLE CREATING VIRTUAL REALITY MAPS OF TUMOURS • 10 investigators & 2 patient advocates • 13 investigators & 2 patient advocates • Canada, Republic of Ireland, Switzerland, UK & USA UK • Bowel, brain, breast & pancreatic • Breast PROFGREG HANNON,CRUK Cambridge Institute • PROF JOSEPHINE BUNCH, NPL £16m £20m mutographs team Precision team IDENTIFYING PREVENTABLE CAUSES OF CANCER PREVENTING UNNECESSARY BREAST CANCER TREATMENT • 6 investigators & 2 patient advocates • 9investigators & 5 patient advocates • France, UK & USA • The Netherlands, UK & USA • Pancreatic, kidney, oesophageal, bowel, lung, liver & bladder • Breast PROF SIR MIKE STRATTON, Sanger Inst. PROF JELLE WESSELING,NKI £20m £15m

  7. 8 CHALLENGES SET IN ROUND 2 DORMANCY Identify and target tumour cells that remain dormant for many years after seemingly effective treatment TREATMENT REGIMENS Define mechanistic rules for combinatorial treatments to overcome resistance and avoid toxicity TUMOUR VACCINOLOGY Create novel tumour vaccinology approaches that establish or enhance successful immune responses beyond what is revealed by current checkpoint therapy CANCER CAUSES Determine the mechanisms that “cause” cancer without known mutagenesis, such as obesity, in order to devise novel interventions ARTIFICIAL INTELLIGENCE Detect cancer earlier by interrogating medical and non-medical data sets using machine and deep-learning MICROBIOTA Improve treatment responses by manipulating the composition and status of the microbiota LETHAL VS NON-LETHAL Distinguish between lethal cancers which need treating, and non-lethal cancers that don’t TISSUE SPECIFICITY Devise approaches to prevent or treat cancer based on mechanisms that determine tissue specificity of some cancer genes

  8. ROUND 2 FUNDED TEAMS SPECIFICANCER team OPTIMISTICC team generate a comprehensive map of cancer drivers and their specificity to different tissues Opportunity To Investigate the Microbiome’s Impact on THE development & Treatment OF Colorectal Cancer • 10 investigators & 3 patient advocates • 13 investigators & 1 patient advocate The Netherlands, UK & USA • Canada, The Netherlands, UK, USA, & Spain • Breast, bowel, brain, kidney, lung pancreatic & skin • Bowel • PROF STEPHEN ELLEDGE, • Harvard Medical School • PROF MATTHEW MEYERSON,Dana-Faber Cancer Institute £19m £20m STORMING CANCER team develop new options to treat and prevent inflammation induced cancer in high-risk patients 11 investigators & 3 patient advocates • PrOF Wendy Garrett, • Harvard TH Chan School of Public Health Canada, Israel, UK & USA • Bowel, lung, oesophageal & stomach • PROF THEA TLSTY, UCSF £20m

  9. Use the following slides to GUIDE idea generation and discussion

  10. WHAT MAKES A GRAND CHALLENGE? • GRAND CHALLENGES SHOULD BE BROAD ENOUGH IN SCOPE TO NOT LIMIT POTENTIAL, YET SPECIFIC ENOUGH TO DRIVE A CRITICAL PATHWAY TOWARDS TANGIBLE, IMPACTFUL OUTCOMES Too broad (e.g. cure cancer) Wide gate to maximise breadth and variety of approaches GRAND CHALLENGE SWEET SPOT? Narrow gate to ensure tangible outcome and impact

  11. EXAMPLE 1 – early detection • FOR SOME AREAS, THE ‘SWEET SPOT’ WITH GREATEST POTENTIAL IMPACT IS LIKELY TO BE CLEAR How can we detect all cancers early? How can we detect, at a stage that would improve clinical outcome, the cancers that are most often diagnosed late? Broadly applicable Cancer specific How can we detect more pancreatic cancers at a stage when they can be effectively resected? How can we define and detect the pre-neoplastic to neoplastic switch? How can we develop a blood test to detect pancreatic cancer at or before stage 2 in 75% of patients? How can we use imaging to detect the pre-neoplastic to neoplastic switch?

  12. TIME TO SHARE IDEAS PRESENT YOUR IDEA COLLECTIVE DISCUSSION SUMMARY SESSION EACH PERSON HAS 3 MINUTES TO PRESENT THEIR CHALLENGE • COLLECTIVE FEEDBACK AND DISCUSSION SESSION BASED ON THE IDEAS PRESENTED ASK FOR FAVOURITE IDEAS AND DISCUSS NEXT STEPS

  13. Submitting ideas and next steps • ALL IDEAS WILL BE SUBMITTED TO CANCER RESEARCH UK FOR REVIEW BY THE SCIENTIFIC ADVISORY PANEL DEADLINE FOR IDEAS: 15 NOVEMBER 2019 NEW CHALLENGES REVEALED: FEBRUARY 2020 EXPRESSION OF INTEREST DEADLINE: JULY 2020

  14. Use the following images as templates for twitpics to use on social media

  15. Add workshop details

  16. Add workshop details

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