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This lecture explores inflammation and stress signaling within the innate immune system, our first line of defense against pathogens. It delineates the rapid inflammatory responses that activate both innate and adaptive immune mechanisms, engaging various cellular players such as blood platelets, macrophages, mast cells, neutrophils, and endothelial cells. Key growth factors involved in these processes, including PDGF and VEGF, are also discussed, offering insights into cellular interactions that contribute to inflammation and immune responses.
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Lecture 14/15 – Inflamation & Stress Signaling BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F
Module 11: Inflamatory responses • Inflammatory responses • The innate immune system is our first line of defense against invading pathogens. • Initiates a vigorous and rapid inflammatory response to attack foreign pathogens • Plays a key role in activating the more slowly developing adaptive immune response. • Activation of specific B and T cells to extend the host defense system • Innate response is carried out by a complex series of cellular interactions, collectively known as the inflammatory response. • Cellular players in the innate immune response/inflamatory response are: • Blood platelets • Macrophages • Mast cells • Neutrophils • Endothelial cells Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
Module 11: Inflamation Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
Module 11: Platelet Structure & Thrombus formation (A) (B) Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
Module 11 Figure platelet activation Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
Module 11: Endothelial Cell Permeability Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
Module 11: Cell Proliferation • Platlet-derived growth factor – PDGF • Transforming growth factor b(TGF-b) • Angiogenesis • Vascular endothelial growth factor (VEGF) Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
Module 11: Cell Proliferation • Platlet-derived growth factor – PDGF • Transforming growth factor b(TGF-b) • Angiogenesis • Vascular endothelial growth factor (VEGF) Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
Module 11: Sphingomyellin Signaling Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
Module 11: Formation and Action of PAMPs Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
Module 2: Toll Receptor Signalling Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
Module 2: Virus Recognition Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
Module 1: Cytokines Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
Module 11: TNFα apoptotic signalling Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
Module 11: Apoptosis Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
Module 11: Figure Bcl-2 family functions Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
Module 2: NF-κB activation Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
Module 11: Macrophage Signalling Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
Module 11: Mast Cell Signalling Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
Module 11: Cell Proliferation Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
