Alanine Transaminase. Alanine Transaminase. Alanine transaminase or ALT is a transaminase enzyme ( EC 220.127.116.11 ). It is also called serum glutamic pyruvic transaminase (SGPT) or alanine aminotransferase (ALT) .
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Normal level in serum:
ALT < 45 units/ml
L-Alanine + α-ketoglutaric acid L-Glutamic acid + Pyruvic
Pyruvic acid + NADH + H+ L-Lactic acid + NAD+
To screen for liver damage and/or to help diagnose liver disease.
When is it ordered?
To evaluate a person who has symptoms of a liver disorder:
Other causes of moderate increases in ALT include obstruction of bile ducts, cirrhosis and with tumors in the liver.
Aspartatetransaminase (AST)also called serum glutamicoxaloacetictransaminase (SGOT) (EC18.104.22.168) is similar to alaninetransaminase (ALT) in that it is another enzyme associated with liver parenchymal cells.
Two isoenzymes are present in humans.
AST <40 units/ml
Glutamic-PyruvicTransaminase (GPT) is found in significant quantities in liver, kidney, and skeletal muscle, in decreasing order. When liver cells are damaged, GOT and GPT levels rise especially early in the disease.
L-Aspartate + α-ketoglutarate L-Glutamate + Oxaloacetate