Lecture 9: Innate Immunity Edith Porter, M.D. MICR 201 Microbiology for Health Related Sciences. Lecture outline. Concept of immunity Innate immunity Adaptive immunity Innate immunity: first line of defense General aspects Physical factors Chemical factors Normal microbiota
Acquired, available within days
In higher vertebrates
First Line of Defense
Second Line of Defense
Skin Tongue Esophagus
Keratinizing in skin
(LPS, PG, etc)
Natural Killer Cells
B-Ly : antibody production
in bone marrow
Clears bacteria and fungi in tissues
Communicates with lymphocytes
Figure 16.9 (3 of 5)
1) Innate immunity is
A) The body's ability to ward off diseases.
B) The body's defenses against any kind of pathogen.
C) The body's defense against a particular pathogen.
D) The lack of resistance.
E) Increased susceptibility to disease.
3) Which of the following does NOT increase blood vessel permeability?
2) The complement protein cascade is the same for the classical pathway, alternative pathway, and lectin pathway beginning with the activation of
4) Which of the following does NOT provide protection from phagocytic digestion?
A) Preventing formation of phagolysosomes
B) Killing white blood cells
C) Causing formation of phagolysosomes
D) Ability to grow at a low pH
+ + +Antimicrobial peptides
+ + +
First line defense from concept to molecules
Emphasis on primary research and hands on training in current methods in innate immunology including flow cytometry
Lec: MW 9:50 - 10:40 am * Lab: M 10:50 – 2:20 pm * Rec: W 10:50 – 11:40 am
Prerequisites: One of the following; MICR 201+MICR 202, MICR 300, BIOL 380, or instructor consent. Questions? email/call Dr. Edith Porter at firstname.lastname@example.org , (323) 343 6353 or drop by at ASCL 355