1 / 22

Sweet’s Syndrome

Sweet’s Syndrome. David Deneau MD Acute Neutrophilic Dermatosis (Sweet RD. Br. J. Dermatol.1964; 76:349-56). Sweet’s Syndrome. Sweet’s Syndrome. Sweet’s Syndrome. Sweet’s Syndrome. Sweet’s Syndrome. Sweet’s Syndrome. Sweet’s Syndrome. Sweet’s Syndrome. Clinical Features

jolene-sutton
Download Presentation

Sweet’s Syndrome

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Sweet’s Syndrome David Deneau MD Acute Neutrophilic Dermatosis (Sweet RD. Br. J. Dermatol.1964; 76:349-56)

  2. Sweet’s Syndrome

  3. Sweet’s Syndrome

  4. Sweet’s Syndrome

  5. Sweet’s Syndrome

  6. Sweet’s Syndrome

  7. Sweet’s Syndrome

  8. Sweet’s Syndrome

  9. Sweet’s Syndrome Clinical Features • Tender to painful red plaques face, hands, arms, upper trunk • Acute onset • Frequently associated with; PMN leucocytosis Fever Arthralgias Malaise

  10. Sweet’s Syndrome Histology • Diffuse neutrophilic infiltrate in upper dermis • Leucocytoclasis • Without evidence of primary leucocytoclastic vasculitis

  11. Sweet’s Syndrome Associated Disorders 50% cases are idiopathic 50% may be associated with underlying disease • Malignancy (20 – 25%) Leukemia Lymphoma Carcinomas

  12. Sweet’s Syndrome Associated Disorders, (continued) • Infection: Streptococcal URI Yersinial GI infection • Pregnancy • Inflammatory Bowel Disease

  13. Sweet’s Syndrome Associated Disorders (continued) • Drug Reactions: G-CSF Minocycline Trimethoprim – Sulfamethoxazole all – trans Retinoic Acid Oral Contraceptives

  14. Sweet’s Syndrome

  15. Sweet’s Syndrome

  16. Sweet’s Syndrome

  17. Sweet’s Syndrome

  18. Sweet’s Syndrome

  19. Sweet’s Syndrome

  20. Sweet’s Syndrome

  21. Sweet’s Syndrome Treatment • Systemic corticosteroids Usually dramatic response 4-6 week tapering course Relapse may occur • Colchicine May be effective in mild disease

  22. Sweet’s Syndrome Treatment (continued) • Potassium iodide • Indomethacin • Dapsone • Cyclosporine • Tetracycline type antibiotics

More Related