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Disorders of W ater and I ons M etabolism

General Pathology – Seminar. Disorders of W ater and I ons M etabolism. Jaroslava Dušková Inst. Pathol. ,1st Med. Faculty, Charles Univ., Prague http://www1.lf1.cuni.cz/~jdusk/. Body Fluids. intracellular extracellular. TBW …total body water. intravascular. extravascular.

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Disorders of W ater and I ons M etabolism

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  1. General Pathology – Seminar Disorders of Water and Ions Metabolism Jaroslava Dušková Inst. Pathol. ,1st Med. Faculty, Charles Univ., Prague http://www1.lf1.cuni.cz/~jdusk/

  2. Body Fluids intracellular extracellular TBW …total body water intravascular extravascular

  3. Daily Intake Drinking 1600 Food 850 Oxidation 350 Total 2800 Normal Water Gains & Losses[~ ml] Daily Otput Urine 1600 Stool 100 Skin 300 Lungs 800 Total 2800

  4. Intracellular Edema • energy (ATP) deficiency statuses – hydropic degeneration – vacuolar dystrophy • Na+/K+ dysbalances (hyperaldosteronism) • hypokalaemia in severe diarrhoea • hyperhydration - water intoxication (infusions!)

  5. Starling´s Hypothesis Net filtration = Forces favoring filtration – Forces opposing filtration Forces favoring filtration: capillary hydrostatic preassure + intersticial oncotic pressure Forces opposing filtration: plasma oncotic pressure + tissue hydrostatic pressure

  6. Edema Def.: accumulation of fluid in the intersticial spaces

  7. Causes & Types of Edema • increased hydrostatic pressure - cardiac • decreased oncotic pressure –hypalbuminotic • blocked lymphatics – lymphostatic • neuromediators - allergic Extent: generalized, localized

  8. Thrombosis Def.: intravital intravascular blood clotting Range: parietal obturative

  9. Types of Thrombi • red stagnation • white fluxe • mixed • hyaline

  10. RES • thrombosis • rheumatis • scurvy • cholelithiasis • appendicitis • Beiträge zur pathologischen Anatomie und zur allgemeinen Pathologie • Beiträge zur Thrombosenfrage Karl Albert Ludwig Aschoff 1866-1942, German

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