Case Study #9 West Nile Virus . Sara Halaszi Yoonhee Choi Daniella Ross November 15, 2007 . (www.geocities.com/.../PagelsTom/02westnile.jpg). The Case: . In late August 1999, an outbreak of mosquito-borne encephalitis occurs in NY state
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November 15, 2007
First discovered in 1937 Uganda, West Nile region
40-60 nm in diameter
One molecule of + sense SS RNA (10,000-11,000 bases)
Member of the Japanese encephalitis virus antigentic complex
Close antigentic relationship with other Flaviviruses (serologic cross-reactions)West Nile Virus
(fever, fatigue, headache, muscle and joint pain)
(encephalitis, meningitis, profound muscle weakness, high fever, seizures, paralysis)
Cases of WNV infection in humans in the USA
(Figures taken from the Centers for Disease Control)
West Nile Virus Activity in United States (1999)
West Nile Virus Activity in United States (2007)
A horse being vaccinated against West Nile virus. Photo courtesy of CDC.
(entered human clinical trials in 2006)
combines yellow fever genes and WNV surface proteins.
uses an existing codon-modified gene-based DNA plasmid vector to express WNV proteins
(Bai, Fengwei et al, “Antiviral Peptides Targeting the West Nile Virus Envelope Protein.” Journal of Virology, Feb. 2007, p. 2047-2055)