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Understanding Pain Sensations: The Broad Spectrum from Touch to Itch

Dive into the basics of pain with Randall Reed, PhD, as he explores the sensory biology behind our senses and the common properties they share. Discover how TRP channels act as gatekeepers for thermal sensation, pain, and taste. Explore the interaction of cells in tissues and the molecular genesis of specialized organelles, shedding light on processes of neuronal damage, repair, and regeneration. Learn about the vulnerabilities of sensory systems and the strategies to modulate sensory perception for pain, auditory, and chemosensory experiences. Gain insights into the key opportunities and practical implications of advances in sensory biology.

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Understanding Pain Sensations: The Broad Spectrum from Touch to Itch

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  1. Pain Day – The Basics of Pain Randall Reed PhD Director Center for Sensory Biology Professor Department of Molecular Biology and Genetics Department of Neuroscience Department of Otolaryngology – HNS

  2. Our Senses Share Many Common Properties • The IBBS Center for Sensory Biology • Randall Reed - olfaction • Paul Fuchs - hearing • Michael Caterina - Pain/touch • Xinzhong Dong - Pain/touch • Craig Montell - vision/taste • Elisabeth Glowatzki - hearing • Jeremy Nathans - vision • King-Wai Yau - vision/olfaction • Angelika Doetzlhofer– hearing • Michael Deans - hearing

  3. Classic View of the Senses • The Five Senses - Provide Information • Vision • Smell • Taste • Hearing • Touch • Also Provide Protection

  4. The Spectrum of Sensations Pain from a Broad Perspective: Touch Itch Pain

  5. TRP Channels: MolecularGatekeepers for the Senses • TRP Channels Mediate: • Thermal Sensation / Pain • Taste Some aspects of: • Vision • Olfaction • Hearing

  6. The Senses: Targets of Environmental Assault • Sensory Systems lie at interface between our inner and outer world – Subject to Damage • Hearing Loss • Burn/Itch • Olfactory Loss • Light Induced Damage

  7. Key Opportunities/Practical Implications of Advances in Sensory Biology • Strategies to modulate (up or down) sensory perception (Pain/Auditory/Chemosensory) • Organization/Interaction of cells in tissues • Molecular and cellular genesis of specialized organelles • Understand processes of neuronal damage, repair and regeneration

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