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Общи анестетици. P r o c a i n e. ASSAY Dissolve 0.400 g in 50 ml of dilute hydrochloric acid R . Carry out the determination of primary aromatic amino nitrogen ( 2.5.8 ). 1 ml of 0.1 M sodium nitrite is equivalent to 27.28 mg of C13H21ClN2O2. Lidocaine. 2,6-Dimethylaniline
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Общи анестетици P r o c a i n e
ASSAY Dissolve 0.400 g in 50 ml of dilute hydrochloric acid R. Carry out the determination of primary aromatic amino nitrogen (2.5.8). 1 ml of 0.1Msodium nitrite is equivalent to 27.28 mg of C13H21ClN2O2 .
2,6-Dimethylaniline Solution (a). Dissolve 0.25 g of the substance to be examined in methanol R and dilute to 10 ml with the same solvent. This solution is used to prepare the test solution. Solution (b). Dissolve 50 mg of 2,6-dimethylaniline R in methanol R and dilute to 100 ml with the same solvent. Dilute 1 ml of the solution to 100 ml with methanol R. This solution is used to prepare the standard. Using three flat-bottomed tubes, place in the first 2 ml of solution ( a), in the second 1 ml of solution (b) and 1 ml of methanol R and in the third 2 ml of methanol R (used to prepare a blank). To each tube add 1 ml of a freshly prepared 10 g/l solution of dimethylaminobenzaldehyde R in methanol R and 2 ml of glacial acetic acid R and allow to stand at room temperature for 10 min. The intensity of the yellow colour of the test solution is between that of the blank and that of the standard (100 ppm).
