The Immune Response. The Third Line of Defense. The third line of defense involves a specific response that is effective against specific pathogens. This involves a specialized group of white blood cells called lymphocytes, which produce antibodies.
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There are many different antigen markers on the membrane of a virus or bacterium.
The attachment of antibodies to the antigens increases the size of the complex, making the antigen-antibody combination more conspicuous and, therefore, more easily engulfed and destroyed by macrophages.