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ANTIMICROBIAL DRUGS.

ANTIMICROBIAL DRUGS. Introduction. KEY TERMS. Chemotherapy. Antimicrobial drugs. Selective Toxicity. Antibiosis. Antibiotic. SPECTRUM: ANTI-MICROBIAL ACTIVITY. Narrow Spectrum. Broad Spectrum. Superinfection. ANTIMICROBIAL ACTION OF DRUGS.

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ANTIMICROBIAL DRUGS.

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  1. ANTIMICROBIAL DRUGS. Introduction.

  2. KEY TERMS. • Chemotherapy. • Antimicrobial drugs. • Selective Toxicity. • Antibiosis. • Antibiotic.

  3. SPECTRUM: ANTI-MICROBIAL ACTIVITY. • Narrow Spectrum. • Broad Spectrum. • Superinfection.

  4. ANTIMICROBIAL ACTION OF DRUGS. • Inhibition of cell wall synthesis: Penicillin. • Inhibition of protein synthesis: Chloramphenicol. • Injury to the plasma membrane: Polymyxin B. • Inhibition of nucleic acid synthesis: Rifampin.

  5. Inhibiting the synthesis of essential metabolites: Sulfanilamide.

  6. INHIBITORS: CELLWALL SYNTHESIS: Penicillins. • Penicillin(Natural). • Semisynthetic penicillins. • Monobactams. • Cephalosporins. • Carbapenems. • Bacitracin, Vancomycin. • Isoniazid,Ethambutol.

  7. IINHIBITORS OF PROTEIN SYNTHESIS. • Aminoglycosides. • Tetracyclines. • Chloramphenicol. • Macrolides.

  8. INJURY TO THE PLASMA MEMBRANE. • Bacitracin. • PolymyxinB.

  9. INHIBITORS OF DNA/RNA SYNTHESIS. • Rifamycins. • Quinolones and Flouroquinolones.

  10. Competitive Inhibitors of Synthesis of Essentials. • Sufanomides.

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