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Dietary Intervention Prevents Dyslipidemia in HIV-1-infected Individuals on HAART: A Randomized Trial

This study examines the effectiveness of dietary intervention in preventing dyslipidemia associated with highly active antiretroviral therapy (HAART) in HIV-1-infected patients. Results show that dietary intervention reduces fat intake and improves lipid profiles.

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Dietary Intervention Prevents Dyslipidemia in HIV-1-infected Individuals on HAART: A Randomized Trial

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  1. Dietary Intervention Prevents Dyslipidemia Associated with Highly Active Antiretroviral Therapy in HIV-1-infected Individuals: A Randomized Trial Rosmeri K. Lazzaretti, RD, MSc, Regina Kuhmmer, RD, MSc, Eduardo Sprinz, MD, ScD, Carísi A. Polanczyk, MD, ScD, Jorge P. Ribeiro, MD, ScD

  2. Objective • To evaluate the efficacy of dietary intervention on blood lipids of HIV-infected patients who are started on highly active antiretroviral therapy (HAART). J Am Coll Cardiol 2012;59:979-88

  3. Background • Current guidelines recommend diet as first step intervention for HIV-1-infected individuals with HAART-related dyslipidemia, but there is no evidence from randomized trials to support this recommendation. J Am Coll Cardiol 2012;59:979-88

  4. Methods • Eighty-three HIV-1-infected patients, naïve from HAART, were randomly assigned to HAART with dietary intervention (Diet, n = 43) or HAART without dietary intervention (Controls, n = 40) for 12 months. • Diet, according to the National Cholesterol Education Program, was given every 3 months. • Before and after intervention, 24 hour food records and lipid profile were obtained. • Data were analyzed by intention to treat, using mixed-effects models. J Am Coll Cardiol 2012;59:979-88

  5. Results • Diet resulted in reduction of percentage of fat intake (from 31±7 to 21±3% of calories), while Controls presented no change in percentage of fat intake. • Plasma cholesterol (151±29 to 190±33 mg/dl) and LDL-C (85±24 to 106 ±31 mg/dl) increased in the Controls but were unchanged in the Diet group. • Plasma triglycerides were reduced by Diet (from 135 ±67 to 101±42 mg/dl) and increased in Controls (from 134±70 to 160±76 mg/dl). • After 1-year follow-up, 21% of patients who received Diet had a lipid profile compatible with dyslipidemia compared to 68% (p < 0.001) of Controls. J Am Coll Cardiol 2012;59:979-88

  6. Study Flow Diagram J Am Coll Cardiol 2012;59:979-88

  7. Effects on Body Mass Index and Blood Lipids Effect of the nutritional intervention during 12 months on body mass index (Panel A), total cholesterol levels (Panel B), LDL-C (Panel C), and triglycerides (Panel D). Values are expressed as mean ± SD. J Am Coll Cardiol 2012;59:979-88

  8. Conclusion • Among HIV-1-positive individuals naïve of previous treatment, Diet prevents dyslipidemia associated with HAART. J Am Coll Cardiol 2012;59:979-88

  9. Clinical Trial Registration: http://www.clinicaltrials.gov. Unique identifier: NCT00429845.

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