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Primetime with Program: Research Project Grants (RPGs) and Training and Career Awards. Francisco S. Sy, NIMHD Shawn Gaillard, NIGMS. What is a grant? Grant-in-Aid = funding mechanism that allows you to carry out independent research on a problem of importance to public health
Francisco S. Sy, NIMHD
Shawn Gaillard, NIGMS
What kinds of RPGs are there?
Who is eligible to apply?
Which Institutes at the NIH award grants?
To support a discrete, specified, circumscribed project on health related research and development based on the stated program interests of one or more of the NIH Institutes and Centers.
R03 Small Research Grant
To provide research support specifically limited in time and amount for studies in categorical program areas such as pilot/feasibility studies, secondary analyses, method/technology development. Small grants provide flexibility for initiating studies which are generally for preliminary short-term projects and are non-renewable.
To support individual research projects in the biomedical and behavioral sciences conducted by faculty, and involving their undergraduate students, who are located in health professional schools and other academic components that have not been major recipients of NIH research grant funds.
R21 Exploratory/Developmental Grant
To encourage new, exploratory and developmental research activities in their early stages of development. Such projects may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models or applications that could have major impact on a field of biomedical, behavioral, or clinical research.
For development of a Phase III clinical trial including establishment of the research team, development of tools for data management and oversight of the research, the definition of recruitment strategies, and finalization of the protocol and other essential elements of the study included in a manual of operations/procedures
R34 Exploratory Clinical Research Grants
Support for research and resources for evaluating feasibility, tolerability, acceptability and safety of novel approaches to improving mental health and modifying health risk behavior. Support resources for obtaining the preliminary data needed as a prerequisite to a larger-scale (efficacy or effectiveness) intervention or services study.
E.g., “From Intervention Development to Services”
To support recipient sponsored and directed international, national or regional scientific meetings, conferences and workshops.
R24 Resource-Related Research Project
To support research projects that will enhance the capability of resources to serve biomedical research.
R25 Education Project
To support the development and/or implementation of a program as it relates to a category in one or more of the areas of education, information, training, technical assistance, coordination, or evaluation.
To support cooperative research and development (R&D) projects between small business concerns and research institutions, limited in time and amount.
R43/R44 Small Business Innovation Research (SBIR) Grants
To support small businesses in developing products or services that may ultimately lead to commercialization.
To support a broadly based, multidisciplinary, multi-investigator, multi-project research program which has a specific major objective or basic theme.
A program project application should have a central research focus, in contrast to the usually narrower thrust of the traditional research project.
Each project supported through this mechanism should contribute or be directly related to the common theme of the total research effort, and should demonstrate an essential element of unity and interdependence.
The grant can also provide support for certain basic resources used by these groups in the program, including clinical components, the sharing of which facilitates the total research effort.
To support planning for new programs, expansion or modification of existing resources, and feasibility studies to explore various approaches to the development of interdisciplinary programs that offer potential solutions to problems of special significance to the mission of the NIH. These exploratory studies may lead to specialized or comprehensive centers.
P30 Center Core Grant
To support shared resources and facilities for use by a number of investigators from different disciplines who provide a multidisciplinary approach to a joint research effort, or from the same discipline who focus on a common research problem.
The center core grant is integrated for shared use by multiple research projects, but funded independently from them.
The center core grant provides more accessible resources than obtainable from individual research or program projects.
To support any part of the full range of health-related research and development from very basic to clinical. These centers may also involve ancillary supportive activities such as protracted patient care necessary to the primary research or R&D effort.
The spectrum of activities provided within the Center will comprise a multidisciplinary attack on a specific disease entity or biomedical problem area. Centers may also serve as regional or national resources for special research purposes.
P60 Comprehensive Center
To support a multipurpose unit designed to bring together into a common focus divergent but related facilities within a given community.
The comprehensive center may be based in a university or may involve other locally available resources, such as hospitals, computer facilities, regional centers, and primate colonies. It may include specialized centers, program projects and projects as integral components.
Regardless of the facilities available to a program, it usually includes the following objectives: to foster biomedical research and development at both the fundamental and clinical levels; to initiate and expand community education, screening, and counseling programs; and to educate medical and allied health professionals concerning the problems of diagnosis and treatment of a specific disease.
To enable institutions to make National Research Service Awards to individuals selected by them for predoctoral and postdoctoral research training in specified shortage areas. This grant enables the director of the program to select the trainees and to develop a curriculum of study and research experiences necessary to provide high quality research training.
T35 NRSA Short-Term Research Training
To provide students in health professional schools with intensive, short-term (such as off-quarters or summer periods) research training experiences to encourage research careers and/or research in areas of national need.
To provide support for predoctoral training which leads to the combined M.D./Ph.D. degrees. Addresses the need for training physicians to become physician-scientists including those conducting translational and patient-oriented research.
F31 Predoctoral Individual National Research Service Award
To provide predoctoral individuals (doctoral candidates) with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.).
Diversity: PA-10-109; http://grants.nih.gov/grants/guide/pa-files/PA-10-109.html
F32 Postdoctoral Individual National Research Service Award
To provide postdoctoral research training within the broad scope of biomedical, behavioral or clinical research to individuals to broaden their scientific background and enhance their potential for research in specified health-related areas.
PA-10-110; http://grants.nih.gov/grants/guide/pa-files/PA-10-110.htmlNRSA Fellowship Awards
To facilitate a timely transition from a mentored postdoctoral research position to a stable independent research position with independent NIH or other independent research support at an earlier stage than is currently the norm.
Two Phases: initial phase (K99) of mentored support to allow the candidate time to obtain additional training, complete research, publish results, and bridge to an independent research position. Second phase(R00) provides support to conduct research toward establishing his/her own independent research program and to prepare an application for regular research grant support (R01).
To provide support for supervised research and training in biomedical, behavioral or clinical sciences that will lead to independence. The career development experience must be in a research area new to the applicant and/or one in which an additional supervised research experience will substantially add to the research capabilities of the applicant.
K08 MentoredClinical Scientist Research Career Development Award
To provide for the development of outstanding clinician research scientists to independence. The supervised research experience may integrate didactic studies with laboratory or clinically-based research, or focus solely on research.
PA-10-059; http://grants.nih.gov/grants/guide/pa-files/PA-10-059.htmlMentored Career Development Awards
To provide support for the supervised career development of clinically trained professionals who have made a commitment of focus their research endeavors on patient-oriented (human subjects) research, and who have the potential to develop into productive, clinical investigators.
K25 Mentored Quantitative Research Development Award
To support the supervised career development of usually junior faculty with quantitative scientific and engineering backgrounds outside of biology or medicine who have made a commitment to focus their research endeavors on behavioral and biomedical research (basic or clinical).
PA-10-062; http://grants.nih.gov/grants/guide/pa-files/PA-10-062.htmlMentored Career Development Awards
To support newly independent scientists who can demonstrate the need for a period of intensive research focus as a means of developing and enhancing the potential of their research careers.
K05 Senior Scientist Research and Mentorship Award
To support outstanding scientists who have demonstrated a sustained, high level of productivity and whose expertise, research accomplishments, and contributions to the field have been and will continue to be critical to the mission of a particular NIH institute or center. The candidate will usually also serve as a mentor to others.
K24 Midcareer Investigator Award in Patient-Oriented Research
To provide support for the clinicians to allow them protected time to devote to patient-oriented (human subjects) research and to act as research mentors for clinical residents, clinical fellows and junior clinical faculty.
PA-10-061; http://grants.nih.gov/grants/guide/pa-files/PA-10-061.htmlNon-Mentored Career Development Awards
Overall Impact:the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved.
Overall Impact:the likelihood for the candidate to maintain a strong research program.
Lack of or weak impact
Significance not obvious or weak
Too ambitious, lacking focus
Unclear or flawed hypothesis
Applicant track record weak or lacks appropriate expertise
Wrong grant mechanism for the project
Carefully read the summary statement
Talk with your Institute PD
Seek help from experienced colleagues/mentors
Submit a carefully considered revised application
Carefully address the critiques
Don’t use your response to rebut reviewers-show them where you agree or disagree and where you’ve made changes
Don’t rush back with an incompletely or hastily revised application
Strong significance to an important problem in public health: IMPACT is high
High degree of novelty and innovation
Strong track record by a well qualified applicantand collaborators
Relevant and supportive preliminary data
Clear and focused approach that provides unambiguous results
Careful attention to details
Presentation, readability, clarity of data, graphics, error bars, spelling, etc