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Comprehensive Pharmacology Review: Key Updates on Cardiovascular and Respiratory Drugs (2004-2005)

This review encompasses the essential pharmacological principles and updates concerning a range of cardiovascular and respiratory drugs, focusing on their mechanisms, classifications, and applications. Highlights include various antibiotics, diuretics, antihypertensives, and anesthetics, alongside dietary supplements and anti-inflammatory agents. The review addresses the role of these drugs in clinical settings, including the treatment of conditions such as hypertension, heart failure, and respiratory issues. Familiarize yourself with significant medications, including Spironolactone, Spectinomycin, and Sulfonamides, and their therapeutic implications.

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Comprehensive Pharmacology Review: Key Updates on Cardiovascular and Respiratory Drugs (2004-2005)

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  1. 2004-2005Pharmacology Reviewof Everything(Principles, Cardiovascular and Respiratory drugs have been updated) 8 September 20147:05 AM

  2. Spectinomycin • AntibioticBacteriostatic protein synthesis inhibitor • 30S ribosome

  3. Spironolactone • Potassium sparing diureticAntiandrogen • Aldosterone receptor antagonistAndrogen receptor antagonistTestosterone synthesis inhibitorAntihypertensiveHeart failure treatment

  4. St. John’s Wort • Dietary supplement • Antidepressant

  5. Streptokinase • Thrombolytic

  6. Streptomycin • Aminoglycoside antibioticBactericidal protein synthesis inhibitor • 30S ribosomeFreezes initiation

  7. Succinylcholine • Paralytic • Depolarizing blockerParalyzes skeletal musclesBronchoconstrictor

  8. Sucralfate • Antiulcer

  9. Sufentanil • OpioidGeneral anaesthetic • Intravenous anaesthetic

  10. Sulfacetamide • Sulfonamide antibioticMicrobial nucleic acidand protein synthesis inhibitor • Inhibits dihydropteroate synthetaseTopical

  11. Sulfadoxine • Sulfonamide antibioticMicrobial nucleic acidand protein synthesis inhibitor • Dihydropteroate synthetase inhibitor

  12. Sulfamethoxazole • Sulfonamide antibioticMicrobial nucleic acidand protein synthesis inhibitor • Inhibits dihydropteroate synthetase

  13. Sulfasalazine • Disease modifyinganti-rheumatic drug (DMARD) • Metabolized to sulfonamide+ salicylate (NSAID)Treatment of IBD

  14. Sulfinpyrazone • Uricosuric • Anti-gout

  15. Sulfisoxazole • Sulfonamide antibioticNucleic acid andprotein synthesis inhibitor • Inhibits dihydropteroate synthetase

  16. Sulfonamides • AntibioticsNucleic acid andprotein synthesis inhibitors • Inhibit dihydropteroate synthetase

  17. Sulindac • NSAIDAnalgesic, Anti-inflammatory, Antipyretic • Cyclooxygenase inhibitor

  18. Suramin • Tropical antiparasitic • Treatment of African Trypanosomiasis

  19. Tacrolimus • ImmunosuppressiveAntineoplastic • Binds FKBP (FK506 binding protein)Inhibits calcineurin

  20. Tamoxifen • Antineoplastic Antiestrogen • Estrogen receptor anatagonist

  21. Tegaserod • IBS treatment • 5HT4 receptor agonist

  22. Telmisartan • Antihypertensive • Angiotensin receptor blocker(ARB)

  23. Temazepam • Sedative/Hypnotic • Benzodiazepine Acts on GABAA receptor complex

  24. Tenecteplase • Thrombolytic • Tissue plasminogen activator (tPA)

  25. Terazosin • Sympatholytic1adrenergic antagonist • AntihypertensiveTreatment for benign prostatic hypertrophy

  26. Terbinafine • Allylamine antifungal • Inhibits ergosterol synthesis by inhibiting squalene epoxidase

  27. Terbutaline • Sympathomimetic2 adrenergic agonist • Short acting bronchodilator TocolyticUterine relaxant

  28. Testosterone • Androgen • Natural male gonadal steroid

  29. Testosterone cypionate • Androgen • Synthetic depot

  30. Testosterone enanthate • Androgen • Synthetic depot

  31. Testosterone propionate • Androgen • Synthetic depot

  32. Tetracaine • Local anaesthetic

  33. Tetracycline • AntibioticBacteriostatic protein synthesis inhibitor Antiulcer • 30S ribosomePrevents aminoacyl tRNA attachment

  34. Thalidomide • AntineoplasticLeprosy treatment • Anti-angiogenicAnti-TNF

  35. Theophylline • Bronchodilator • MethylxanthinePhosphodiesterase inhibitorUsed in asthma

  36. Thiabendazole • Antihelminthic • Treatment of intestinal roundworms

  37. 6-Thioguanine • Antineoplastic • Antimetabolite (“pseudofeedback inhibition” of HGPRT and PRP – purine synthesis)

  38. Thiopental • General Anaesthetic • Ultra-short-acting barbiturate

  39. Thioridazine • Antipsychotic • Phenothiazine

  40. Thiotepa • Antineoplastic • Alkylating agent

  41. Thiothixene • Antipsychotic

  42. Thrombopoietin • Cytokine • Platelet synthesis stimulator

  43. Thromboxane A2 (TXA2) • Autacoid • Promotes platelet aggregation Cyclooxygenase product of arachidonate metabolism

  44. Thyrotropin-releasing Hormone (TRH) • Hypothalamic hormone • Stimulates release of thyroid stimulating hormone (TSH) from the anterior pituitary

  45. ThyrotropinThyroid-stimulating Hormone (TSH) • Anterior pituitary hormone • Stimulates production of thyroxine (T4), triiodothyronine (T3) and thyroglobulin

  46. Ticarcillin • Penicillin antibioticCell wall synthesis inhibitor • Anti-pseudomonal penicillinInhibits peptidoglycan cross-linking

  47. Ticlopidine • Antiplatelet • ADP receptor antagonist

  48. Timolol • Sympatholytic adrenergic antagonist • AntihypertensiveGlaucoma treatmentAnti-anginalBronchoconstrictor

  49. Tissue plasminogen activators alteplase, reteplase, tenecteplase • Thrombolytics

  50. Tobramycin • Aminoglycoside antibioticBactericidal protein synthesis inhibitor • 30S ribosomeFreezes initiation

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