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Identifying Melanoma Wavelengths: Role of Pigment on Skin Cancer Development

Study on the effects of pigment on melanoma development using UV wavelengths, genetic strains, and GFP induction. Acknowledgements to research contributors and funding sources.

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Identifying Melanoma Wavelengths: Role of Pigment on Skin Cancer Development

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  1. IDENTIFYING THE MELANOMA WAVELENGTHS E. De Fabo, EOH, SPHHS, GWUMC drmecd@gwumc.edu 202-994-3975

  2. 6/18 (1.0) BLACK 20/24 (3.7) ALBINO Effect of pigment on melanoma E. De Fabo, EOH, SPHHS, GWUMC

  3. FVB HGF/SF FVB HGF/SF C57BL6 HGF/SF C57BL6 HGF/SF UVB UVA STRAIN 1 STRAIN 2 De Fabo et al., Cancer Res., 2004; in prep. E. De Fabo, EOH, SPHHS, GWUMC

  4. GFP Induction 24 Hrs Post-DoxR.Zaidi, NCI,NIH • Pups were injected doxycycline on the day of birth. • Back skins were harvested 24 hours after the doxycycline injection and imaged for GFP. Dct-rtTA–/ GFP+ Dct-rtTA+ / GFP+ E. De Fabo, EOH, SPHHS, GWUMC

  5. UVB + PIGMENT STRAIN-2 UVA + PIGMENT STRAIN-2 UVB + ALBINO STRAIN-1 UVA + ALBINO STRAIN-1 E. De Fabo, EOH, SPHHS, GWUMC

  6. ACKNOWLEDGEMENTS • THE GEORGE WASHINGTON UNIVERSITY • SCHOOL OF PUBLIC HEALTH & HEALTH SERVICES • FRANCES NOONAN • JESSE BAHN • SCHOOL OF MEDICINE & HEALTH SCIENCES • TERESA HAWLEY • ALI RAMEZANI • NIH/NCI • RAZA ZAIDI: Laboratory of Cancer Biology & Genetics • GLENN MERLINO: Chief, Laboratory of Cancer Biology & Genetics • PAUL MELTZER: Chief, Cancer Genetics Branch • Funding- NCI/NIH; Elaine Snyder Cancer Research Fund, GWUMC E. De Fabo, EOH, SPHHS, GWUMC

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