ultimate skin protection

1. ultimate skin protection the science of nimuespf

2. nimue old vs new the evolution of nimue sunscreen 1994 2012

3. penetration of UV radiation into the skin

4. effect of UV rays on skin histology • DNA fragmentation • repetitive UVA exposure responsible for • loss of fragment from mitochondrial DNA in human skin cells • disrupts mitochondria functioning • impairs energy formation • results = accelerated skin ageing damage occurring in the skin cell

5. effect of UV rays on skin histology 35 year old covered skin – no sun damage 57 year old exposed sun damaged skin

6. general sunscreen development traditional sunscreens (1980’s and 1990’s) • mild UVB filters, assist tanning not prevent burning • higher SPF products developed to prevent sunburn • more people used sunscreens • increase of skin cancers increased • conclusion sunscreens should also contain UVA filters (now legislated in most countries

7. general sunscreen development traditional sunscreens • UV-A filters tested found unstable exposure to sunlight=photo-toxicity • free radical formation due to breakdown of sun filters • no DNA protection • Titanium and Zinc Oxides sunscreens • good for children’s skin • difficult to balance SPF and UVA protection

8. nimue sunscreen development rationale for change • technology & testing facilities improve – formulations evolve = ever increasing market • Improved ingredients • sun protection largest growth sector predicted in skincare • changes in consumer attitudes • best blends of modern sunscreens contain: • organic and inorganic sunscreens • photo-stabilizers • anti-oxidants

9. general requirements for new sunscreens modern sunscreen formulations should • protect against UVA and UVB radiation • provide high sun protection factor (spf) • be photostable • be water resistant • be cosmetically elegant • be non-toxic • provide balance between performance and skin feel

10. sunscreen labeling requirements new EU recommendationson the efficacy of sunscreen products: labeling of final product „The category of the sunscreen should be indicated on the label at least as prominently as the sun protection factor“ Commission recommendation of 22 September 2006 on the efficacy of sunscren products and the claims made relating thereto,Offical Journal of the European Union, 2006/647/EC

11. new sunscreen labeling standards

12. nimue sunscreen updates prerequisites consumer trends and demands high protection values high protection sunscreen efficacy according to new EU regulations and cosmetic safety report – july 2013 cost contributionto formulation regulatory approval for various countries water resistancy formulation ability UVA & UVB protection maximum safety and skin compatibility balance between performance and skin feel

13. regulatory news • new cosmetic regulations from July 2013 to align with European rules for manufacturing and labelling • from July 2013, nano ingredients must be specified in the ingredient list, ie. “titanium dioxide (nano)” and new labeling regulations • new cosmetics legislation expected in 2013 • proposed rule to limit the maximum SPF value on sunscreen labels to 50

14. new nimue spf 40 formulation • 15.5% sunscreen provides SPF40 (reduced sun filters and double spf) • environmentally friendly preservative system • new PEG free and plant derived emulsion system provides lighter feel with good stability • solubilisers of sunscreens allow for increased SPF • less sunscreen usage = reduces risk of photo allergies

15. new nimue spf 40 formulation • provides high UVA-PF Coverage for US and Canada • Japanese rating PA+++ • passes Australian requirements • contains water repellency active- enhances SPF • advanced antioxidant complex • improved skin feel with high performance

16. new nimue spf 40 ingredients sunscreens PHENYLBENZIMIDAZOLE SULFONIC ACID (PBSA) • Skin Deep Cosmetic Safety Review Rating is 2/10 BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE (BMT) • Skin Deep Cosmetic Safety Review is 0/10 Skin Deep Cosmetic Safety Review ratings are rated 1-10 with 1 being low and 10 being extremely hazardous

17. new nimue spf 40 ingredients sunscreens POLYCRYLENE • Skin Deep Cosmetic Safety Review is 0/10 • SPF booster • photostabilizer of UVA sunscreen POLYSILCONE-15 • Skin Deep Cosmetic Safety Review is 2/10 TITANIUM DIOXIDE •  Skin Deep Cosmetic Safety Review is 0/10 Skin Deep Cosmetic Safety Review ratings are rated 1-10 with 1 being low and 10 being extremely hazardous

18. new nimue spf 40 ingredients actives • UVA absorbers prevent mutations in skin • anti-oxidant needs to be added in addition to Vitamin C POLYMER • enhances SPF • allows lower levels of sunscreen to ensure less phototoxicity YEAST POLYSACCHARIDES • activates immune system of skin with • protective effect on skin against damage • smoothes wrinkles

19. new nimue spf 40 ingredients actives DIMETHYLMETHOXY CHROMANOL • very powerful anti-oxidant • protects human fibroblasts against oxidative stress • protects cells from irreversible damage TOCOPHERYL ACETATE • vitamin E  • anti-oxidant SODIUM ASCORBYL PHOSPHATE • vitamin C • anti-oxidant

20. new nimue spf 40 formulation • added UVA stabilizers • very powerful anti-oxidants to protect DNA, stem cells and immune system • moisturisation • use organis and inorganic sunscreens • clinically tested spf 

21. new nimue spf 40 formulation the total photo protective system • new technology + ingredients • conforms to market trends and demands • exclusive prestige formulation for use on face for high protection • compliments nimue skin health programme

22. new nimue spf 40 formulation the total photo protective system • suitable for all skin classifications • sensory experience • conforms to new regulations –formulation and labelling

23. new packaging

24. general marketing claims • less sunscreen chemicals used yet double the SPF achieved • milder, safer sunscreen ingredients used • UVA protection - anti-ageing • powerful anti-oxidants • non-whitening formula • clinically tested

25. ultimate skin protection the science of nimuespf