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In-vivo trial results of a novel ultrasonic cough stimulator. Jennifer C. Nitz, PhD, MPhty, BPhty; John Perrier, BPhty; Peter Cook, MBBS, FANZCA, FCICM. Aim Establish: Whether ultrasound (US) stimulation can safely stimulate cough. Most efficient US frequency.

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in vivo trial results of a novel ultrasonic cough stimulator

In-vivo trial results of a novel ultrasonic cough stimulator

Jennifer C. Nitz, PhD, MPhty, BPhty; John Perrier, BPhty; Peter Cook, MBBS, FANZCA, FCICM

slide2

Aim

    • Establish:
      • Whether ultrasound (US) stimulation can safely stimulate cough.
      • Most efficient US frequency.
      • Whether single- or dual-sided stimulation is more effective.
  • Relevance
    • Ability to cough voluntarily is absent or diminished in many clinical situations, which may predispose patients to or prolong respiratory diseases.
method
Method
  • Applied stimulation with CoughStim device to 15 nondisabled and 7 unable-to-cough volunteers:
    • Unilaterally: 8 frequencies and 2 power levels.
    • Bilaterally: 2 frequencies and 3 power levels.
results
Results
  • Nondisabled subjects
    • Cough stimulated:
      • 80% at 0.58 MHz and 9 W unilaterally.
      • 75% at 0.58 MHz and 6 W bilaterally
  • Unable-to-cough subjects
    • Cough stimulated:
      • 71% at 0.54 MHz and 6 W bilaterally.
conclusion
Conclusion
  • CoughStim device:
    • Regularly and safely produced moderately strong cough response in subjects with or without ability to cough.
    • Produced this effect without causing undue discomfort.