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An autonomous molecular computer for logical control of gene expression. Yaakov Benenson, Binyamin Gil, Uri Ben-Dor, Rivka Adar & Ehud Shapiro Weizmann Institute of Science, Israel.

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an autonomous molecular computer for logical control of gene expression

An autonomous molecular computer for logical control of gene expression

Yaakov Benenson, Binyamin Gil, Uri Ben-Dor, Rivka Adar & Ehud Shapiro

Weizmann Institute of Science, Israel

slide2
An autonomous biomolecular computer that, logically analyzes the levels of mRNA species, and in response produces a molecule capable of affecting levels of gene expression, which is a drug.
  • Logical design and modular organization
    • Input - Identification of disease indicators
    • Computation - Diagnosis
    • Output – Drug administration
example diagnostic rules
Example diagnostic rules
  • Small-cell lung cancer
    • If ASCL1↑ & GRIA2↑ & INSM1↑ & PTTG↑ then Administer TCTCCCAGCGTGCGCCAT (oblimersen-a drug that may kill cancer cells by blocking the production of a protein that makes cancer cells live longer. Also called bcl-2 antisense oligodeoxynucleotide G3139 and augmerosen)
  • Prostate cancer
    • If PPAP2B↓ & GSTP1↓ & PIM1↑ & HPN↑ then Administer GTTGGTATTGCACAT(MDM2 antisense strand)