http:// en.wikipedia.org /wiki/File:Protein_MSH2_PDB_2o8b.png. MSH2. And Its Role in Cancer. About. mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli ) Tumor suppressor 2805 base pairs 16 exons Mutations are distributed evenly across gene
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And Its Role in Cancer
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
2805 base pairs
Mutations are distributed evenly across gene
Heterodimer with DNA binding and ADP binding
DNA mismatch repair (MMR)
Wind, et al., 1995
Cranston, et al. 1997
Msh2-/- and p53-/- female
Cranston, et al. 1997.
Wildtype female embryo
Msh2-/- and p53-/- female embryo