slide1 n.
Download
Skip this Video
Loading SlideShow in 5 Seconds..
MSH2 PowerPoint Presentation
Download Presentation
MSH2

Loading in 2 Seconds...

play fullscreen
1 / 10

MSH2 - PowerPoint PPT Presentation


  • 118 Views
  • Uploaded on

http:// en.wikipedia.org /wiki/File:Protein_MSH2_PDB_2o8b.png. MSH2. And Its Role in Cancer. About. mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli ) Tumor suppressor 2805 base pairs 16 exons Mutations are distributed evenly across gene

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'MSH2' - jed


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
about
About

mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)

Tumor suppressor

2805 base pairs

16 exons

Mutations are distributed evenly across gene

Heterodimer with DNA binding and ADP binding

http://ghr.nlm.nih.gov/gene/MSH2

what is the protein s normal role in the cell
What is the Protein’s Normal Role in the Cell?

DNA mismatch repair (MMR)

  • Removing misincorporated nucleotides
    • base-base mismatches
    • insertion/deletion loops
  • Trinucleotide repeat expansion (TRE)
protein s biological role in the organism
Protein’s Biological Role in the Organism

Wind, et al., 1995

Cranston, et al. 1997

slide6

Msh2-/- and p53-/- male

Msh2-/- and p53-/- female

Cranston, et al. 1997.

Wildtype female embryo

Msh2-/- and p53-/- female embryo

protein s role in cancer
Protein’s Role in Cancer
  • Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome)
  • Muir-ToreeSyndrome
  • Mismatch repair cancer syndrome
lynch syndrome hnpcc
Lynch Syndrome (HNPCC)

http://www.myriadresourceguide.com/colaris/risk.htm

treatment
Treatment

http://www.polyposisregistry.org.uk/history/history2.htm

http://www.ccsb.org/Cancer/Summary/CDR0000062963/

references
References
  • http://ghr.nlm.nih.gov/gene/MSH2
  • http://ghr.nlm.nih.gov/condition/lynch-syndrome
  • http://omim.org/entry/609309
  • http://omim.org/entry/120435
  • http://genefacts.org/index.php?option=com_content&view=article&id=492:management&catid=113:lynch-syndrome&Itemid=665
  • http://www.myriadresourceguide.com/colaris/genes.htm
  • Peña-Diaz, Javier. Mammalian mismatch repair: error-free or error-prone?Trends in Biochemical Sciences. May 2012 Vol. 37, No. 5
  • Wind, Niels et al. Inactivation of the Mouse Msh2 Gene Results in Mismatch Repair Deficiency, Methylation Tolerance, Hyperrecombination, and Predisposition to Cancer. Cell. July 1995 Vol. 82, 321-330.
  • Cranston et al. Female embryonic lethality in mice nullizygous for both Msh2 and p53. Nature. 1997.