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Histology Laboratories Molecules to Systems 2003 Compiled by James D. Jamieson, MD/PhD

Histology Laboratories Molecules to Systems 2003 Compiled by James D. Jamieson, MD/PhD Thomas L. Lentz, MD. No part of this image collection may be distributed outside of the Yale University Intranet. Acknowledgements. Sources of Micrographs, Diagrams and Figures.

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Histology Laboratories Molecules to Systems 2003 Compiled by James D. Jamieson, MD/PhD

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  1. Histology Laboratories Molecules to Systems 2003 Compiled by James D. Jamieson, MD/PhD Thomas L. Lentz, MD No part of this image collection may be distributed outside of the Yale University Intranet.

  2. Acknowledgements Sources of Micrographs, Diagrams and Figures Alberts, B. et al. Molecular Biology of the Cell. 4th Edition, Garland Science, New York, 2002. Gartner, L. P. and Hiatt, J. L. Color Atlas of Histology, Williams & Wilkins, Baltimore, 1994. Kerr, J. B. Atlas of Functional Histology. Mosby, London, 1999. Kessel, R. G. and Kardon, R. H. Tissues and Organs: a text-atlas of scanning electron microscopy. W. H. Freeman, San Francisco, 1979. Lentz, T. L. Cell Fine Structure. W. B. Saunders, Philadelphia, 1971. Lodish, H. et al. Molecular Cell Biology. W. H. Freeman, New York, 2000. Mizoguti, H. Color Slide Atlas of Histology. Nihon Shashin Shinbunsha, Tokyo. Young, B. and Heath, J. W. Wheater’s Functional Histology. Churchill Livingstone, Edinburgh, 2000. Micrographs taken by George Palade, Marilyn Farquhar, James D. Jamieson, Nicolai Simionescu, Maya Simionescu, David Castle, Thomas L. Lentz. Web Resources http://info.med.yale.edu/webpath/webpath.htm Cushing Library Educational Software/Cell Biology/Several Histology Resources

  3. Lymphoid System Laboratory

  4. Plasma Cell

  5. Germinal Center (GC) Peyer’s Patches (Lymphoid Follicles) in Small Gut

  6. Diffuse GALT in gut lamina propria Organized GALT/MALT GALT: gut-associated lymphoid tissue MALT: mucosa-associated lymphoid tissue

  7. Lymphoid follicle Germinal center Peyer’s Patch

  8. Afferent lymphatic Subcapsular sinus Cortex Efferent lymphatics Medullary cords Hilus Medulla Lymph Node Secondary follicles

  9. Cortex Medulla Germinal centers Lymph Node

  10. Afferent lymphatic with valve (V) Subcapsular sinus

  11. Germinal center: B cell proliferation and maturation Mantle of resting and memory B cells Secondary Follicle

  12. Reticulin stain of lymph node

  13. Palatine tonsil

  14. Cortex Medulla Thymus

  15. Cortex (developing T cells) Medulla Thymus

  16. Thymic medulla with Hassall’s corpuscles

  17. Hassall’s corpuscles

  18. Development of T cells in Thymus

  19. Spleen

  20. White pulp Red pulp PALS Trabeular artery Spleen

  21. B cell mantle GC Central arteriole PALS (T cells) Spleen

  22. Venous sinus Endothelial cells Spleen Red Pulp

  23. Direction of blood flow in spleen

  24. Organization of the spleen

  25. Some Pathology

  26. Benign Reactive Lymph Node

  27. Benign Reactive Lymph Node Which cells are responding?

  28. Adenocarcinoma Metastases to Lymph Node How did the tumor cells get to this location?

  29. Adenocarcinoma Metastases to Lymph Node How did the tumor cells get to this location?

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