slide1 n.
Download
Skip this Video
Loading SlideShow in 5 Seconds..
Genetics: PowerPoint Presentation
Download Presentation
Genetics:

Loading in 2 Seconds...

play fullscreen
1 / 2

Genetics: - PowerPoint PPT Presentation


  • 95 Views
  • Uploaded on

CurePSP Research Roadmap. Scientific Hypotheses. Genetics: W ork out the cellular pathways controlled by the top 10 genes from CurePSP’s 2011 whole genome marker analysis and its 2014 whole exome sequencing project. Prions:

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'Genetics:' - jaron


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
slide1

CurePSP

Research Roadmap

Scientific Hypotheses

Genetics:

Work out the cellular pathways controlled by the top 10 genes from CurePSP’s 2011 whole genome marker analysis and its 2014 whole exome sequencing project.

Prions:

Work out steps in tau misfolding, templating and cell-to-cell transmission

Proteins:

Identify defects in production, handling and disposal of tau and other proteins in PSP/CBD

Procedures

Identify top 30-50 drug targets

Perform high-throughput screens

in molecular or cellular models

Test drugs in vertebrate preclinical models

New Experimental Tools

Models:

Create new cellular and animal lab models more faithful to human PSP/CBD

Early-phase clinical trials by industry or academia

Markers:

Devise better tests for diagnosis and measurement of PSP/CBD and its treatment response in humans

Late-phase clinical trials by industry

curepsp research roadmap
CurePSP Research Roadmap
  • A general guide to the research topics that CurePSP sees as the path to PSP/CBD prevention
  • Uses the CurePSP-sponsored whole-genome SNP and WES results as a starting point for drug development.
  • Provides perspective/overview for potential donors.
  • Does not prohibit funding grants on other topics.
  • Are any updates/additions/deletions needed?