CurePSP Research Roadmap. Scientific Hypotheses. Genetics: W ork out the cellular pathways controlled by the top 10 genes from CurePSP’s 2011 whole genome marker analysis and its 2014 whole exome sequencing project. Prions:
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Work out the cellular pathways controlled by the top 10 genes from CurePSP’s 2011 whole genome marker analysis and its 2014 whole exome sequencing project.
Work out steps in tau misfolding, templating and cell-to-cell transmission
Identify defects in production, handling and disposal of tau and other proteins in PSP/CBD
Identify top 30-50 drug targets
Perform high-throughput screens
in molecular or cellular models
Test drugs in vertebrate preclinical models
New Experimental Tools
Create new cellular and animal lab models more faithful to human PSP/CBD
Early-phase clinical trials by industry or academia
Devise better tests for diagnosis and measurement of PSP/CBD and its treatment response in humans
Late-phase clinical trials by industry