Announcements. “Lab” is still tomorrow We will meet in Ellison 204 We will have a quick info session on group projects We will have a lecture on Ch. 14 Part 2 No class on Friday unless you want to turn in homework
Think back to the lab where we examined all the places bacteria live and remember our skin and mucous membranes are covered in microbes…
Why don’t we get sick more when we are bombarded with bacteria?
We have defenses! YAY!
or general pathways that are elicited
A) How does your body eliminate the invader and cure itself?
B) How does your body respond when you encounter the infection for a second time?
First Line of Defense: Innate Immunity
Before you stepped on the nail, what protected you from the nail?
Hint: It is related to your body and not your clothing
Bacteria get past the physical barriers when you step on the nail…
You have additional first-line of defenses!
Antimicrobial substances and Normal Flora
Your first line of defenses fail you and now bacteria from the nail are in your foot causing an infection.
INNATE IMMUNE RESPONSE!
-2 responses at once!
Complement is activated after the first line of defenses fail you when you step on a nail…
What is the result of each?
Which innate cells come to the rescue to resolve the infection from the nail?
How do these cells know where to go? What attracts them to the site of infection vs. a sterile place?