1 / 32

Asbestos Fate, Exposure, Remediation, and Adverse Health Effects

Asbestos Fate, Exposure, Remediation, and Adverse Health Effects. Director: Ian A. Blair, Ph.D. Deputy Director: Trevor M. Penning, Ph.D. NIEHS Grant: P42ES023720. Asbestos sites in EPA regions. Questions submitted to CEET by Ambler community. Can asbestos be remediated?

janestevens
Download Presentation

Asbestos Fate, Exposure, Remediation, and Adverse Health Effects

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Asbestos Fate, Exposure, Remediation, and Adverse Health Effects Director: Ian A. Blair, Ph.D. Deputy Director: Trevor M. Penning, Ph.D. NIEHS Grant: P42ES023720

  2. Asbestos sites in EPA regions

  3. Questions submitted to CEET by Ambler community • Can asbestos be remediated? • Is asbestos transported by water? • Why is there a cluster of mesotheliomas among women in Ambler? • Is there a genetic pre-disposition to asbestos-induced mesothelioma? • Can asbestos-induced mesothelioma be prevented? • Is it possible to develop blood tests for asbestos exposure and mesothelioma?

  4. Penn SRP Projects & Cores

  5. Penn SRP Center Web Site http://www.med.upenn.edu/asbestos/

  6. Project 1: Remediation of Asbestos Particles Co-PIs: Jane Willenbring and Brenda Casper (School of Arts and Sciences, University of Pennsylvania) Hypothesis: it will be possible to discover and quantify new, better ways to remediate asbestos sites in situ using a combination of hyper-accumulating plants and plants native to naturally metal rich serpentine soils coupled with their associated arbuscular mycorrhizal fungi (AMF)

  7. Soil Sampling at BoRit Site Soil for capping

  8. Bioremediation: Conceptual Processes

  9. Project 2: Mobility and Fate of Asbestos in Water Co-PIs: Douglas J. Jerolmack and Jane Willenbring (School of Arts and Sciences, University of Pennsylvania) Hypothesis: the mobility of asbestos particles in groundwater has been underestimated, and the unusually large aspect ratio and material properties make asbestos transport significantly different from other fine particles

  10. Real-time observations of dynamics and aggregate formation of asbestos in water 10min 0min 30min 20min 10μm 10μm

  11. Trajectories of asbestos particles in water

  12. Project 3: Social and Spatial Determinants of Asbestos Risk in a Superfund EJ Community Co-PIs: Frances Barg and Edward A. Emmett (Perelman School of Medicine, University of Pennsylvania) Hypothesis: The incidence of mesothelioma is related to occupational and non-occupational exposures in the Ambler area, to the proximity to the site, and to various social, lifestyle and economic factors

  13. Materials and Methods Retrospective cohort study Data 1930 US Census 1930 US Life Tables National Death Index Data elements Age Gender Race Occupation Address Exposures of interest Occupational exposure Paraoccupational exposure Environmental exposure

  14. Project 4: Integrated Models of Malignant Mesothelioma Co-PIs: Joseph R. Testa (Fox-Chase Cancer Center) and Rebecca Simmons (Perelman School of Medicine, University of Pennsylvania) Hypothesis: Mutations in key tumor suppressor genes as well as epigenetic modifications, represent key molecular changes in mesothelial cell physiology that collectively contribute to mesothelioma formation following exposure to asbestos. The identification and characterization of such alterations may afford novel opportunities for early diagnosis, prevention and therapy.

  15. Accelerated mouse models of asbestos-induced malignant mesothelioma (MM) Bap1+/+ Survival Bap1+/- Weeks post initial asbestos exposure

  16. Project 5: : Chemoprevention of Asbestos-Induced Malignant Mesothelioma Co-PIs: Melpo Christofidou-Solomidou and Steven M. Albelda (Perelman School of Medicine, University of Pennsylvania) Hypothesis: Secoisolariciresinol diglucoside (SDG) will interfere with inflammasome activation and ROS generation in asbestos-activated macrophages and mesothelial cells and thus interfere with initiation and propagation of damaging processes that would ultimately lead to mesothelioma formation

  17. Flaxseed lignan complex (FLC) in mouse models

  18. Effect of FLC on SV40 TAg mice

  19. Project 6: Biomarkers of Asbestos Exposure Co-PIs: Ian A. Blair and Anil Vachani (Perelman School of Medicine, University of Pennsylvania) Hypothesis: Unsupervised serum metabolomics analysis using ultra-high resolution Liquid Chromatography-Mass Spectrometry will reveal novel biomarkers of biological response to asbestos that can be characterized

  20. A new approach to discovery of mesothelioma biomarkers Asbestos exposed (n=40) Mesothelioma (n=40)

  21. Mesothelioma biomarkers: summary Tabata 2013

  22. Penn SRP Center Cores • Administrative • Community Engagement • Research Translation • Biostatistics Research • Inter-Disciplinary Training Core

  23. Community Engagement Core Co-PIs: Edward Emmett and Fran Barg (Perelman School of Medicine, University of Pennsylvania) Hypothesis: Concerns of the community can be translated into research projects

  24. Penn SRP Center: local impact

  25. Penn SRP Center: Biomarkers and Ambler BoRit site

  26. Research Translation Core Co-PIs: Richard Pepino and Robert Schenkel (Perelman School of Medicine, University of Pennsylvania) Hypothesis: The knowledge and discoveries of the Center can be translated into actionable items that will remediate asbestos waste (Projects 1 and 2) and reduce its adverse health effects (Projects 3-6) by forging productive partnerships with the public and private sectors

  27. Research Translation Core Committee Members • Technology Development & Transfer (TDT) includes . . . • Richard Pepino, Ian Blair, Trevor Penning, Robert Schenkel (PCI), Jane Willenbring (Project 1 PI), David Mandelbaum (Superfund Attorney), Sachin Shankar (PA-DEP), Deborah Burgin (ATSDR,HQ) William Hagel (EPA,ORD), and Samantha Beers (EPA, EJ) • Research Translation & Application (RTA) includes . . . • Richard Pepino, Marilyn Howarth, Douglas Jerolmack (Project 2 PI), Francis Barg (CEC), Lora Werner (ATSDR), Charlie Root (EPA /OSC), Jill Lowe (EPA/Ambler Supervisor), Josh Barber EPA/OSC), Barbara Allerton (PA-DOH), and Catherine Klinger Kutcher (Philadelphia DOH)

  28. TDT and RTA Committee roles in technology transfer Interdisciplinary Training Core • Inventions and patents • Recommendations • Target opportunities • Develop metrics RTA TDT PIs of Projects • Policy issues • Regulation changes • Legislative fixes • Risk assessment protocols Stake-holders Program Director Metrics and evaluations • Assess research • Practical • Reasonable • Implementable Regulatory Agencies, CEC, Local Government, Private/Public Partnerships, Healthcare System National Forum Policy & Practice Best Management Practices Patents Removal Investigation/ Feasibility Studies PCI Products Process Marketing Risk Assessment

  29. Inter-Disciplinary Training Core Co-PIs: Trevor M. Penning and Jane Willenbring (Perelman School of Medicine, University of Pennsylvania) Mission. The Interdisciplinary Superfund Research Training Program provides cross-training in environmental science and environmental health science to ensure that all trainees master the necessary skills and have a sufficient knowledge base to understand the hazards of superfund waste sites and use this knowledge to help remediate these sites and their ensuing health effects.

  30. Inter-Disciplinary Training Core Approved By Biomedical Graduate Studies and School of Arts & Sciences Fall 2014

  31. Inter-Disciplinary Training Core • Integrated Curriculum • -New Superfund Hazardous Waste and Adverse • Health Effects Course • Optional Training Experiences • -Externships with USEPA • -Penn Center for Innovation Fellows Program • -Community Engagement • Penn CEET/SRP Seminar Series • Penn CEET/SRP Annual Symposium

  32. Acknowledgements Penn SRP Center

More Related