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College of Medicine Faculty Council November 6 th , 2001 Alistair Webb College of Veterinary Medicine 392 4700 X3828 webb@ufl.edu The battle for the program still lies ahead IACUC’S ROLE: represent society’s concerns regarding the welfare of animal subjects
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College of Medicine Faculty Council November 6th, 2001
Alistair Webb College of Veterinary Medicine 392 4700 X3828 webb@ufl.edu
The battle for the program still lies ahead
IACUC’S ROLE: represent society’s concerns regarding the welfare of animal subjects
USDA > Animal Welfare Act [rabbits & major mammals] PHS > OLAW > The Guide [any vertebrate]
UF has 3 IACUCs • 01 HSC • 02 IFAS • 03 CLAS
UF’S ASSURANCE to OLAW
DUTIES • semi-annual review of program • biannual inspection of facilities • report to IO major and minor deficiencies & justify deviations • review complaints and reports of non-compliance
DUTIES Cnt’d • make recommendations to IO on program, facilities and personnel training • review and approve, require modifications, or withhold approvals of proposed animal use • suspend non-compliant activities involving animals
DUTIES Cnt’d • make recommendations to IO on program, facilities and personnel training • review and approve, require modifications, or withhold approvals of proposed animal use • suspend non-compliant activities involving animals
THE 3 R’s REPLACEMENT REDUCTION REFINEMENT
THE PROCESS Development Screening Member Consideration Designated Reviewer or Convened meeting [aka Full Committee]
DEVELOPMENT forms on the web AV involvement IACUC Office
(iv) Procedures that may cause more than momentary or slight pain or distress to the animals will: (A) Be performed with appropriate sedatives, analgesics or anesthetics, unless withholding such agents is justified for scientific reasons, in writing, by the principal investigator and will continue for only the necessary period of time; (B) Involve, in their planning, consultation with the attending veterinarian or his or her designee; (C) Not include the use of paralytics without anesthesia; (v) Animals that would otherwise experience severe or chronic pain or distress that cannot be relieved will be painlessly euthanized at the end of the procedure or, if appropriate, during the procedure; 9 CFR 2.31.d.iv
SCREENING correctness of form disposition 1 FC DR
MEMBER CONSIDERATION after AV consulted 5 working days concerns?` advise DR refer FC
DESIGNATED REVIEWER appointed by Chair approves modifies refers APPROVABLE
DESIGNATED REVIEWER time table – set by FC 1 week > reminder + 2 weeks return to office 6 weeks > withdrawn
CONVENED MEETING protocols available 5 working days half members = quorum 1° & 2° reviewers
CONVENED MEETING approve approve with modifications table disapprove
APPROVABLE > APPROVED signed hard copy to office electronic copy provided
REVIEWING ELECTRONIC PROTOCOLS
MS Word 2000 exchange comments via e-mail attachments
How the Investigator reads the comment
DOs and DON’Ts Visit the web site
Do down-load latest form
Do read [follow] the instructions
Do complete the form yourself
Do remain in compliance
incorporate flexibility follow protocol keep to numbers allowed don’t keep animals in lab check animals daily seek veterinary advice early PI is the responsible person show compassion for your animals
Don’t expect miracles
Don’t procrastinate
Don’t cut and paste your grant
Don’t be technical in the lay language section
Don’t create subject numbers
IRB vs IACUC subject numbers details of what happens to subjects no need for ICF no conflict of interest issues
“Ways to Create Investigator‑friendly interaction and speed up the process”
dichotomy – animals & science remember we are all colleagues do our homework respond promptly speed limits & the law