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College of Medicine Faculty Council November 6 th , 2001 Alistair Webb College of Veterinary Medicine 392 4700 X3828 webb@ufl.edu The battle for the program still lies ahead IACUC’S ROLE: represent society’s concerns regarding the welfare of animal subjects

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Presentation Transcript
slide2

Alistair Webb

College of Veterinary Medicine

392 4700 X3828

webb@ufl.edu

slide3

The battle

for the program

still lies ahead

slide4

IACUC’S ROLE:

represent society’s concerns

regarding the welfare of

animal subjects

slide5

USDA > Animal Welfare Act

[rabbits & major mammals]

PHS > OLAW > The Guide

[any vertebrate]

slide6

UF has 3 IACUCs

  • 01 HSC
  • 02 IFAS
  • 03 CLAS
slide7

UF’S

ASSURANCE

to OLAW

slide8

DUTIES

  • semi-annual review of program
  • biannual inspection of facilities
  • report to IO major and minor

deficiencies & justify deviations

  • review complaints and reports of

non-compliance

slide9

DUTIES Cnt’d

  • make recommendations to IO on program,

facilities and personnel training

  • review and approve, require modifications,

or withhold approvals of proposed animal use

  • suspend non-compliant activities involving

animals

slide10

DUTIES Cnt’d

  • make recommendations to IO on program,

facilities and personnel training

  • review and approve, require modifications,

or withhold approvals of proposed animal use

  • suspend non-compliant activities involving

animals

slide11

THE 3 R’s

REPLACEMENT

REDUCTION

REFINEMENT

slide12

THE PROCESS

Development

Screening

Member Consideration

Designated Reviewer

or

Convened meeting

[aka Full Committee]

slide13

DEVELOPMENT

forms on the web

AV involvement

IACUC Office

slide14

(iv) Procedures that may cause more than momentary or slight pain

or distress to the animals will:

(A) Be performed with appropriate sedatives, analgesics or

anesthetics, unless withholding such agents is justified for

scientific reasons, in writing, by the principal investigator

and will continue for only the necessary period of time;

(B) Involve, in their planning, consultation with the attending

veterinarian or his or her designee;

(C) Not include the use of paralytics without anesthesia;

(v) Animals that would otherwise experience severe or chronic pain or

distress that cannot be relieved will be painlessly euthanized at the

end of the procedure or, if appropriate, during the procedure;

9 CFR 2.31.d.iv

slide15

SCREENING

correctness of form

disposition

1

FC

DR

slide16

MEMBER CONSIDERATION

after AV consulted

5 working days

concerns?`

advise DR

refer FC

slide17

DESIGNATED REVIEWER

appointed by Chair

approves

modifies

refers

APPROVABLE

slide18

DESIGNATED REVIEWER

time table – set by FC

1 week > reminder

+ 2 weeks return to office

6 weeks > withdrawn

slide19

CONVENED MEETING

protocols available 5 working days

half members = quorum

1° & 2° reviewers

slide20

CONVENED MEETING

approve

approve with modifications

table

disapprove

slide21

APPROVABLE > APPROVED

signed hard copy to office

electronic copy provided

slide23

MS Word 2000

exchange comments via

e-mail attachments

slide24

How the Investigator

reads the comment

slide27

DOs and DON’Ts

Visit the web site

slide28

Do

down-load latest form

slide29

Do

read [follow] the instructions

slide30

Do

complete the form yourself

slide31

Do

remain in compliance

slide32

incorporate flexibility

follow protocol

keep to numbers allowed

don’t keep animals in lab

check animals daily

seek veterinary advice early

PI is the responsible person

show compassion

for your

animals

slide33

Don’t

expect miracles

slide34

Don’t

procrastinate

slide35

Don’t

cut and paste your grant

slide36

Don’t

be technical in the lay language section

slide37

Don’t

create subject numbers

slide38

IRB vs IACUC

subject numbers

details of what happens to subjects

no need for ICF

no conflict of interest issues

slide40

dichotomy – animals & science

remember we are all colleagues

do our homework

respond promptly

speed limits & the law