Multiple Chemical Sensitivity. Misnomer – call it Hypersensitivity Causes – are obvious Science - under development. Community Outrage. Multiple Chemical Sensitivity.
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Misnomer – call it Hypersensitivity
Causes – are obvious
Science - under development
Multiple Chemical Sensitivity (MCS) is discussed in detail in the recent Wagerup Parliamentary Inquiry Report page 22: This condition has a range of symptoms:
muscle cramps and pains
mucous membrane irritation, nose bleeds
frequent micturition and thirst
dry persistent cough, sore throat
cognitive function impairment with short term memory loss
Naturally a combination of these symptoms leads to frustration and despair.
Researchers in North Carolina found 16 to 33 percent of the people interviewed reported that they are unusually sensitive to chemicals, and in the California and New Mexico health departments’ surveys 2 percent to 6 percent reported that they have been diagnosed as having multiple chemical sensitivities.
Ref: IEQ Indoor Environmental Quality
(2005, National Institute of Building Sciences)
According to a 1986 U.S. House of Representatives Report:
"In 1986, the National Academy of Sciences targeted fragrances as one of the six categories of chemicals that should be given high priority for neurotoxicity testing. The other groups include insecticides, heavy metals, solvents, food additives and certain air pollutants. The report states that 95 percent of chemicals used in fragrances are synthetic compounds derived from petroleum.
They include benzene derivatives, aldehydes, and many other known toxics and sensitizers, which are capable of causing cancer, birth defects, central nervous system disorders and allergic reactions "
Olfaction studies in the Department of Otorhinolaryngology at Leicester Royal Infirmary have detected a previously unreported, variable phenomenon – ‘superosmia’ – in which subjects' olfaction threshold concentrations are up to 100,000 smaller than the average value.
Two per cent of subjects demonstrated the superosmic phenomenon on single testing, and 10 per cent demonstrated this phenomenon on variable occasions during repeated testing.
C M Philpotta, P Goonetillek, P C Goodenough, A Clark and G E Murty The Journal of Laryngology & Otology (2008), 122:805-809 Cambridge University Press
“Important information for prescribers:
Hypersensitivity to a product or to related compounds is an
U.S. Department of Labor
Occupational Safety & Health Administration (OSHA) regulations
A Case of Sick House Syndrome in Which the Main Symptom Was Allergy to Formaldehyde
Masanori OGAWA 1, Shuta NISHINAKAGAWA 2,
Fumiko YOKOSAWA 2, Hiroyuki GOTO 3,
Toshihiro KAWAMOTO 4 and Yoko ENDO 1
1Occupational Poisoning Center, 2Environmental Health
Research Center, Tokyo Rosai Hospital, 3Environmental
Health Research Center, Kansai Rosai Hospital and
4Department of Environmental Health, University of
Occupational and Environmental Health, Japan
Sari DK, Kuwahara S, Tsukamoto Y, et al.
Effect of prolonged exposure to low concentrations of formaldehyde on the corticotropin releasing hormone neurons in the hypothalamus and adrenocorticotropic hormone cells in the pituitary gland in female mice.
Brain Res 2004; 1013:107–116.
Chronic beryllium disease results from hypersensitivity to beryllium and may occur at much lower exposures than acute beryllium pneumonitis.
A small number of the cases occurred among people living near the plants but who were not occupationally exposed.
People with beryllium-induced contact dermatitis react to patch testing (Curtis, 1951; DeNardi et al., 1952).
Patch testing may cause a flare of the dermatitis in sensitized people; it may also induce beryllium sensitivity (Curtis, 1951)
Susceptibility to chronic beryllium disease varies between individuals, and the disease may develop after low environmental exposures in some people. (ref IARC monograph)
Allergenic extracts for scratch or prick testing produce erythema or erythema and weal reactions in patients with significant IgE mediated sensitivity to the relevant allergen.
This allergic inflammatory response, although not completely understood, is thought to begin with reaction of antigen with IgE on the surface of basophils or mast cells, which initiates a series of biochemical events resulting in the production of histamine and other mediators. These, in turn, produce the immediate-type 'weal and flare' skin reaction. (ref MIMS)
Allergenic extracts may potentially elicit a severe life threatening systemic reaction, rarely resulting in death. Therefore, emergency measures and personnel trained in their use should be available immediately in the event of such a reaction. Patients should be instructed to recognise adverse reaction symptoms and cautioned to contact the doctor if symptoms occur. (ref MIMS)
“it must be remembered that allergenic extracts are highly potent in sensitive individuals and overdose could result in anaphylactic symptoms.”
Used by Alcoa in cooling towers, banned in some countries (e.g. German Biocide Act)
Lymphocyte Transformation test for Diagnosis of Isothiazoline Allergy in Man
Stejskal VDM et al The Journal of Investigative Dermatology 1990 94 798-802
Small particles of Alumina generate reactive oxygen metabolites in human Leukocytes
Ref: Nagase M, Nishaya H, Takeuchi H, Scandinavian Journal of Rheumatology 1995, 24, 102-7
Alumina gel injections into the temporal lobe of rhesus monkeys cause complex partial seizures and morphological changes found in human temporal lobe epilepsy
Ref: Ribak et al Journal of Comparative Neurology 1998, 401, 266-90
Evaluation of Several Variations of the Mouse Ear Swelling Test (MEST) for Detection of Weak and Moderate Contact Sensitizers.
Sailstad DM; Tepper JS; Doerfler DL; Selgrade MK
Govt Reports Announcements & Index (GRA&I), Issue 09, 1994 [NTIS] 20
Validation Of A Minimal Transcript Biomarker Set To Differentiate Between Sensitizers And Irritants In The Local Lymph Node Assay.
Foster WR; Ladics GS; Glatt CM
Toxicologist 2004 Mar;78(1-S):43 [MTGABS]
A survey of suppression of public health information by Australian governments
Boshra Yazahmeidi and C . D .Arcy J . Holman
School of Population Health, The University of Western Australia
“Conclusion: The suppression of public health information is widely practised by
Implications : Systemic interventions are necessary to preserve the integrity of public health research conducted with government involvement.”
(Aust N Z J Public Health. 2007 ;31 :551-7 )