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Transplanteer 1 millioen muis, of humane MAPCellen In C57BL/6 mice or Nude mice

Behandeling. Transplanteer 1 millioen muis, of humane MAPCellen In C57BL/6 mice or Nude mice Laser Doppler voor 21 days Zwem-capaciteit voor 21 d Treadmill voor 21 d Histology. Luttun et al J Clin Invest In Press.

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Transplanteer 1 millioen muis, of humane MAPCellen In C57BL/6 mice or Nude mice

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  1. Behandeling • Transplanteer 1 millioen muis, of • humane MAPCellen • In C57BL/6 mice or Nude mice • Laser Doppler voor 21 days • Zwem-capaciteit voor 21 d • Treadmill voor 21 d • Histology Luttun et al J Clin Invest In Press

  2. Muis MAPCellen differentieren (in part) tot gladde spier, endothelium en skeletale spier ECs SMCs Sk Muscle Luttun et al J Clin Invest In Press

  3. Significante functionele verbetering en bijna geen fibrose in MAPCellen behandelde dieren

  4. Significante functionele verbetering en bijna geen fibrose in MAPCellen behandelde dieren

  5. Zelfde resultaat in dieren met ~PVD die behandeld zijn met muis of humane MAPCellen Luttun et al J Clin Invest In Press

  6. Zelfde resultaat in dieren met ~PVD die behandeld zijn met muis of humane MAPCellen mMAPC1 mMAPC2 hMAPC Luttun et al J Clin Invest In Press

  7. Wanneer realiteit? #1 #2 #3 ... Genetische ziektes Diabetes Ischemie been Beroerte Hartinfarct Parkinson Ruggemergletsel Leverziekte Alzheimer?? Bloedziektes Arthritis Botontkalking Hartinfarct? Nieuwe medicaties Inzicht in ziektebeeld

  8. Hoe realiteit: Stamcelinstituut Leuven (SCIL) GMP-productie faciliteit Basis Preklinisch Klinische (Phase I/II) Bloedstamcel Delforge, Boogaerts, Verfaillie Hart + vaatziekten Janssens, Carmeliet, Luttun Hersenziekten Robberecht Bot, kraakbeen, spier Luyten, Sampaolesi Diabetes Mathieu MAPC / ESC biologie Verfaillie Immunologie Van Gool, Billiau, Waer Beeldvorming Mortelmans, Van Laere, Debyser, Baekelandt, Marchal, Himmelreich http://www.kuleuven.be/scil/

  9. Who did the work • Middelbaar: Evan Cobb, Nicole Ali, Ricky Jones, Sophie Rapaport, Sam Bjork • Bachelor/Master studenten: Sarah Aldrich, Zach Kastenberg, Eric Rarhman, Aaron Lisberg, Jil Webber, Jeremy Alred, Jennifer Gravel, Ben Wildenbring, Adriaan Campo, Qing Cai, David Zwaenepoel, Janiq Beckers, Maria Aelberts, Antonio LoNigro, Simone Calzolari, Jasper Wouters, Tine Verryckt, Olivier Govaere • Doctoraat Studenten: Morayma Reyes, Eugene Liu, Craig Eckfeldt, Rob Schwartz, Eric Mendenhall, Lucas Chase, Sarah Frommer, Terry Burns, Fernando Ulloa, Ben Kidder, Shannon Buckley, Scott Dylla, Avinash Jayashwal, Catherine Flynn, Karen Pauwelijn, Kartik Subramanian, Yonsil Park, Annelies Crabbe, Valerie Roobroeck, Helene Schoemans,Qing Cai, Abhisheck Sohni, Jason Owens, Philip Roelandt • Medische Studenten: Dave Deyle, Sjoban Keel, Troy Lund, Zubaid Rafique, Raul Munoz • Post-docs: Balkrishna Stephanie Salesse, Mo Dao, Mojca Jongen, Anskar Leung, Michel Delforge, Koen Theunissen, Ravi Bhatia, Pankaj Gupta, Jahaghirdir, Huilin Qi, Dean Aguiar, Kazu Sudo, Aernout Luttun, Yves Heremans, Miguel Barajas, Behnan Sahin, Uma Lakshmipathy, Beatriz Pelacho, Rik Snoeckx, Kris Van Den Bogaert, Carlos Clavel, Pau Sancho, Fernando Ulloa-Montoya, Takeshi Shimizu, Martine Gevaert, Camilla Esguera, Jeroen Declercq, Anujit Kapur, Bipasha Bose • Laboranten: Marc Blackstad, Todd Lenvik, Kathy Boland, Jingbo Du, Paul Marker, Molly Holte, Laura Lien, April Breyers, Nihma Estheban, Annelies Deman, Tine Decuyper, Vicky Raets, Manja Muytjens, Nathalie Feyaerts, Arjun Menon, Nele Peersman, Ellen Konings, Sarah Mertens • Collaboraties (Minnesota): John Wagner, Jeff Miller, Walter Low, Bruce Blazar, Wei-Shu Hu, David Largaespada, Bob Tranquillo, Wei Chen, Jennifer Hall, Robert Miller, Tim O’Brien, Jay Zhang, Electra Coucovanis, Sue Keirstadt, Nobuaki Kikyo, Yasushi Nakagawa, Xin Wang, Dan Kaufman, Meri Firpo, Yuehua Jiang, Jakub Tolar, Steve McLoon, Stephen Ekker • Collaboraties (niet Minnesota): Yukari Muguruma, Felipe Prosper, Irv Weissman, Sanjeev Gupta, Dorothee Von Laere, Rose Masereeuw, Michael Ott, Minoru Ko, Shin-Ichi Nischikawa, Shinja Yamanaka, Dirk Deruyscher, Markus Manz, Ernest Arenas, Maurizio Muraca… • Collaboraties (Leuven): Marc Boogaerts, Michel Delforge, Marc Waer, An Billiau, Stefan Janssens, Frank Luyten, Chantal Mathieu, Luc Mortelmans, Zeger Debyser, Koen Van Laere, Veerle Baekelandt, Guy Marchal, Uwe Himmelreich, Wim Robberecht, Thierry Vandendriessche, Marinee Chuah, Peter Carmeliet, Mieke Dewerchin, Bart Hansen, Herman Nijs, Paul Schotsmans, Geert Carmeliet, Hugo Vankelecom, Yves Moreau, … • Collaboraties (Belgie): Jef Pinxteren, Danny Pipeleers, Harry Heimberg, Vera Rogiers, Zwi Berneman, Peter Ponsaerts, Annemarie Vanderlinden, Niels Hellings, Stefaan Desmedt, …

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