Non-Invasive Detection of Bladder Cancer via Tumor-Related Transcript Markers in Urine

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This study explores the non-invasive detection of bladder cancer (BCa) by measuring tumor-related transcript markers in urine. Key genes such as survivin, XIAP, and Ki67 are identified for their roles in apoptosis inhibition and cell proliferation. Over-expression of these markers is correlated with higher cancer stages and poorer prognosis. The study evaluates both tissue and urine specimens, presenting median values to demonstrate the effectiveness of these markers as diagnostic tools and potential therapeutic targets in bladder cancer management.

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Dec 04, 2025

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Non-Invasive Detection of Bladder Cancer via Tumor-Related Transcript Markers in Urine

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Non-invasive detection of bladder cancer by measurement of tumor-related transcript markers in urine Juliane Schmidt, Catharina Rippel, Woei-Yun Siow, Susanne Füssel, Axel Meye, Oliver W. Hakenberg
BCa-related genes • survivin & XIAP: inhibitor of apoptosis proteins (IAP) • Ki67: proliferation marker, essential for cell cycle progression • selectivelyover-expressedin most human malignancies incl.BCa • associationbetween over-expression and higherstage & gradeand withunfavorable prognosis • suitablemarkers(tissue and urine specimens ) andtherapeutic targetsfor BCa