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An Investigation on the Evolution of Autoimmune Disease, Specifically Crohns Disease

An Investigation on the Evolution of Autoimmune Disease, Specifically Crohns Disease. Stephen Palma- Marinaro Period 1 6/11/13. Ancient Lifestyle and Diet . Westernized diet. Non-Westernized Diet. Low Blood Pressure Excellent Insulin Sensitivity Lower Body Mass Index

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An Investigation on the Evolution of Autoimmune Disease, Specifically Crohns Disease

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  1. An Investigation on the Evolution of Autoimmune Disease, Specifically Crohns Disease Stephen Palma-Marinaro Period 1 6/11/13

  2. Ancient Lifestyle and Diet

  3. Westernized diet

  4. Non-Westernized Diet • Low Blood Pressure • Excellent Insulin Sensitivity • Lower Body Mass Index • Lower waist/Height ratio • Better Visual Activity • Lower Fracture Rates • Better Bone health

  5. Industrial Revolution 1760-1830 • Rise of Factories • Separation of household and plant

  6. Autoimmune Diseases

  7. Crohn’s Disease • Autoimmune disease that produces an inflammatory condition of the gastrointestinal tract. • Genetics • NOD2 gene defect • Bacterial flora of gut • Mycobacterium aviumParatuberculosis (MAP) • Bacteroides • Smoking • Stress • Diet*

  8. Crohn’s Disease (Economoua & Pappas, 2007) (Head & Jurenka, 2003) 400,000-500,000 cases of Crohn’s disease in the U.S.A. 2007 reports highest incidence rates in: New Zealand, Canada, Scotland, France, Netherlands and Scandinavia.

  9. Link Between Modern Diet and Crohn’s Autoimmune diseases are rare or virtually absent in hunter-gatherers and non-westernized populations.

  10. Treatments for Crohn’s Disease Conventional Treatments: Surgery, Elemental Diet, Antibiotics, Corticosteroids

  11. Works Cited • American Autoimmune Related Diseases Association, Inc. http://goo.gl/maps/PeQgE (accessed • 27 November 2012). • Andoh, A., H. Imaeda., T. Aomatsu., O. Inatomi., S. Bamba., M. Sasaki., Y. Saito., TTsujikawa. And Y. Fuhiyama. 2011. Comparison of the fecal microbiota profiles between • ulcerative colitis and Crohn’s disease using terminal restriction fragment length • polymorphism analysis. Journal of Gastroenterology 46:479-486. • Bach, J.F.? 2002. Increasing rate of Crohn's Disease and other immune disorders. New England Journal of Medicine347:911-920. • Baylor College of Medicine. The Human Microbiome Project. • http://www.bcm.edu/molvir/microbiome (5 December 2012). • Hermon-Taylor, J. 2001. Mycobacterium aviumsubspecies paratuberculosis: the nature of the • problem. Food Control 12:331-334. • Lindeberg S. 2010. Food and Western Disease: Health and Nutrition from an Evolutionary • Perspective. Chichester, UK: Wiley-Blackwell. • United States National Library of Medicine. Immune Response. • http://www.nlm.nih.gov/medlineplus/ency/article/000821.htm (accessed 28 November 2012).

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