indoleamines l.
Download
Skip this Video
Loading SlideShow in 5 Seconds..
Indoleamines PowerPoint Presentation
Download Presentation
Indoleamines

Loading in 2 Seconds...

play fullscreen
1 / 34

Indoleamines - PowerPoint PPT Presentation


  • 207 Views
  • Uploaded on

Indoleamines. Lisham Ashrafioun Michele San George. Melatonin. vivo.colostate.edu. Melatonin. Receptors (ML1A) CNS locations SCN (biological clock) Anterior pituitary (seasonal breeding) PNS locations Retina - circadian and reproductive responses

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'Indoleamines' - jaden


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
indoleamines

Indoleamines

Lisham Ashrafioun

Michele San George

melatonin
Melatonin

vivo.colostate.edu

melatonin3
Melatonin
  • Receptors (ML1A)
    • CNS locations
      • SCN (biological clock)
      • Anterior pituitary (seasonal breeding)
    • PNS locations
      • Retina - circadian and reproductive responses
      • Cardiovascular system - caudal artery that potentiates NE-induced contraction
      • Reproductive system – ovaries
      • Immune system – T cells
      • Kidneys – Na retention
      • GI Tract – relaxes smooth muscles (melatonin-5-HT feedback)
serotonin

Serotonin

5-Hydroxytryptamine (5-HT)

synthesis
Synthesis

Tryptophan

Tryptophan

5-Hydroxytrophan (5-HTP)

Hydroxylase

Amino Acid

5-Hydroxytryptamine (5-HT)

Decarboxylase

metabolism
Metabolism

Monoamine

5-HT

5-HIAA

Oxidase

5-HIAA: 5-Hydroxy indole amine acid

distribution pns
Distribution(PNS)
  • Majority released from gut
    • Responsible for smooth muscle contractions
    • Release stimulated by food intake
    • Inhibits release of gastric acid
    • Softens stool
  • Cardiovascular system – vasoconstrictor/vasodilator of vessels
    • Bonchioconstriction
  • Uterine contractions
distribution rodent
Distribution: rodent

(Cooper, Bloom, Roth, 2003)

5ht receptors

receptor

5HT1

5HT2

5HT3

5HT4

5ht5

5ht6

5HT7

subtype

5HT1A, 5HT1B, 5HT1D, 5ht1E, 5HT1F

5HT2A, 5HT2B, 5HT2C

5HT3A, 5HT3B

5ht1A, 5ht1B

major signaling pathway

cAMP↓

IP3

ion channel

cAMP

cAMP?

cAMP

cAMP

5HT Receptors
4 families of receptors
4 Families of Receptors
  • Channel linked (Ionotropic)
  • G-protein coupled (Metabotropic)
  • Kinase- linked (enzymatic)
  • Intracellular (gene transcription)
the major g proteins
The Major G Proteins
  • GsStimulatory- Activates Ca channels, activates adenylyl cyclase
  • GiInhibitory- Activates K channels, inhibits adenylyl cyclase
  • Gq– Activates phospholipase C
  • Go - Inhibits Ca channels
  • G12/13 – Diverse ion transporter interactions
second messengers adenylyl cyclase
Second Messengers- Adenylyl Cyclase

http://www.endocrinesurgeon.co.uk

second messenger phospholipase c
Second Messenger- Phospholipase C

http://www.endocrinesurgeon.co.uk

5ht 1a receptor
5HT1A receptor

CNSforum.com

the swiss army knife of neurotransmitters
Depression

Anxiety

Social phobia

Schizophrenia

Obsessive-compulsive

Panic disorder

Migraine

Hypertension

Pulmonary hypertension

Eating disorders

Vomiting

Irritable bowel syndrome

The Swiss army knife of Neurotransmitters
serotenergic drugs
Serotenergic Drugs
  • 5HT1A Buspirone, ipsapirone treat anxiety, depression (partial agonist)
  • 5HT1D Sumatriptan, treat migraine (partial agonist)
  • 5HT2A/2C methysergide, trazodone, risperidone, ketanserin treat migraine, depression, schizophrenia (antagonist)
drugs continued
Drugs continued…
  • 5HT3 Ondansetron treat chemotherapy- induced emesis (antagonist)
  • 5HT4 Cisapride treat GI disorders (agonist)
  • 5HT transporter SSRIs (Fluoxetine, sertraline) treat depression, OCD, panic disorder, social phobia, post traumatic stress disorder (inhibitor)
antidepressants
Antidepressants
  • Decreased amounts and impaired function of 5-HT associated with aggression, depression and other forms of antisocial behavior
  • Antidepressants attempt to increase 5-HT levels
serotonin syndrome
Serotonin Syndrome
  • Toxic, potentially fatal effects
  • require a combination of serotonergic agents, such as an SSRI with an MAOI.
  • Symptoms: euphoria, drowsiness, sustained rapid eye movement, overreaction of reflexes, rapid muscle contraction,abnormal movements of the foot, drunk, dizzy feeling,high body temperature, shivering , diarrhea ,loss of consciousness, death
treatment
Treatment
  • suspected agents should be discontinued
  • OTC drugs containing ingredients known to increase serotonin levels, such as dextromethorphan, pseudoephedrine or phenylpropanolamine, also should be discontinued.
  • Benzodiazepines for mild to moderate cases
  • Cyproheptadine, Methysergide, and Propranolol for severe cases
slide29

Oh man I just saw God and he was playing a mandolin and he told me to watch Fear and Loathing in Las Vegas while listening to The Doors self-titled album and dude they totally go togetherLSD

  • Non-selective 5HT agonist/partial agonist
  • Ergot derivative
  • Mimics 5HT at 5HT1A autoreceptors on raphe cell bodies, slows firing rate of serotonergic neurons
  • Current theories focus on glutamate release in thalamocortical terminals, causing dissociation between sensory relay and cortical output
hallucinogens and drug discrimination trials
Hallucinogens and drug discrimination trials
  • Animal model thought to reflect subjective effects
  • Mediated by activation of 5HT2A receptors
  • Acts as partial or full agonist at 5HT2A and 5HT2C receptors
  • Phenethylamine derivatives (psilocybin) are selective 5HT2A/2C agonists
human studies
Human Studies
  • Psilocybin and PET imaging studies- pattern resembles brain activation in schizophrenic patients
  • Action of psilocybin is blocked by pretreatment with 5HT2A/2C antagonists
yeah rub vaseline on my eyelids 5 ht mdma
Yeah rub Vaseline on my eyelids – 5-HT & MDMA
  • MDMA causes an increased release of 5-HT and blocks reuptake
  • High affinity for SERT
  • Effects fine axons
  • Responsible for temperature increases