PRODUCTION OF NANO PARTICLES USING SUPERCRITICAL CO2. By Satya Chaitanya Class 702 - Modules in nano pharmaceuticals Dr.Rajesh Dave. What is S uper C ritical F luid? A fluid is compressed beyond its Pc and heated beyond its Tc. Why we choose CO2:
702 - Modules in nano pharmaceuticals
Why we choose CO2:
The solubility can be correlated by using the equation
An empirical expression for density is given below
with a Bubble Dryer.
RESS-SC is a modification of
RESS process and overcomes the
limitations of RESS.
Setup is divided into 3 parts
Pre extraction chamber (section I).
Extraction chamber (section II).
Expansion chamber (section III).
RESS–SC process. Circles-drug particles, Stars-SC particles.
I, inline filter; U, ultrasonic processor; P, pump for drug solution; R, precipitation chamber; SCF pump, supply of supercritical CO2; G, pressure gauge; C, heating coil with temperature controller.
size of the precipitated GF nanoparticles Volume of long needle shaped GF crystals obtained
versus power supply to the ultrasound transducer, for power 75 W.
values of power supply using DCM as solvent. (a) No power supply, (b) 60 W power supply, (c) 90 W power supply, (d) 120 W
power supply, (e) 150 W power supply, (f) 180 W power supply. Magnification is ×1000
Pneumatic atomization Decompressive atomization
Amorphous or crystalline particles have been produced, depending on the process temperatures and the chemical characteristics of the solid solute.
HMR1031 concentration (50 to 150 mg/ml) in the methanol solution.
SEM observations revealed that SAA micronized particles are spherical whereas the jet-milled particles are irregular in shape.
Particles from SAA
Particles from Jet-mill