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Basics of Transfusion Therapy. Laura Cooling MD, MS Associate Medical Director Transfusion Medicine. Blood Transfusion Policies and Standard Practices. www.pathology.med.umich.edu Select: Clinical Resource “Blood Bank and Transfusion Services” Link on UMHS Clinical Homepage.

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basics of transfusion therapy

Basics of Transfusion Therapy

Laura Cooling MD, MS

Associate Medical Director

Transfusion Medicine

blood transfusion policies and standard practices

Blood Transfusion Policiesand Standard Practices

www.pathology.med.umich.edu

Select: Clinical Resource

“Blood Bank and Transfusion Services”

Link on UMHS Clinical Homepage

practical guide to transfusion medicine

Practical Guide to Transfusion Medicine

PRINT RESOURCE:

By Marian Petrides, Gary Stack

AABB Press

slide4

THINK PINK

PINK TOP TUBE

FOR BLOOD BANK

SPECIMENS ONLY

blood collection
Blood Collection
  • Most components results of single whole blood donations
  • 500 mL blood + anticoagulant
  • 20-30 min
  • Blood processed into components
    • packed RBC, FFP, platelets, cryo
    • Manufactured Components: IVIgG, albumin, factor concentrates, etc….
anticoagulants preservative
Anticoagulants-Preservative
  • Anticoagulant: Sodium citrate
    • prevent coagulation through chelation Ca++
  • Carbohydrate: Dextrose
    • RBC utilize glycolytic pathway
  • Buffer: Na Phosphate
    • Counter lactic acid acumulation
  • Adenine: Support ATP production
  • Mannitol: Stabilize RBC membrane
slide8

ABO TYPES

Fucose a1-2Galactose-R

H-Antigen

GalNAca1-3Gal-R

Gala1-3Gal-R

2

2

Fuca1

Fuca1

A-Antigen

B-Antigen

slide9

DISTRIBUTION AND COMPATIBILITY

OF ABO TYPES AND BLOOD COMPONENTS

(holds true for solid organ transplant as well)